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Submit ReviewCeranib 1
说明： Ceramidase inhibitor; antiproliferative
化学名： 3-[(2E)-3-(4-Methoxyphenyl)-1-oxo-2-propen-1-yl]-6-methyl-4-phenyl-2(1H)-quinolinone
纯度： ≥98% (HPLC)
生物活性 for Ceranib 1
Ceranib 1 is a ceramidase inhibitor; inhibits proliferation in SKOV3 ovarian carcinoma cells (IC50 = 3.9 μM). Induces accumulation of ceramide species and decreases sphingosine and sphingosine-1-phosphate (S1P) levels in SKOV3 cells.
技术数据 for Ceranib 1
| 分子量 | 395.45 |
| 公式 | C26H21NO3 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 328076-61-5 |
| PubChem ID | 5761166 |
| InChI Key | OJMCCNQNCSCAJV-RVDMUPIBSA-N |
| Smiles | O=C2C(C(/C=C/C4=CC=C(OC)C=C4)=O)=C(C3=CC=CC=C3)C1=CC(C)=CC=C1N2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Ceranib 1
参考文献 for Ceranib 1
参考文献是支持产品生物活性的出版物。
Draper et al (2011) Discovery and evaluation of inhibitors of human ceramidase. Mol. Cancer Ther. 10 2052 PMID: 21885864
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关键词: Ceranib 1, Ceranib 1 supplier, Ceranib1, supplier, ceramidase, inhibitors, inhibits, antiproliferative, ceramides, accumulation, sphingosine, 1, phosphate, s1p, Ceramidases, 4448, Tocris Bioscience
1 篇 Ceranib 1 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Ceranib 1 的部分引用包括：
Davis (2015) The ATP-Binding Cassette Transporter-2 (ABCA2) Overexpression Modulates Sphingosine Levels and Transcription of the Amyloid Precursor Protein (APP) Gene. Sci Rep 12 847 PMID: 26510981
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