Cevimeline hydrochloride

Cat. No. 3689 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Selective M₁ agonist

别名： AF 102B,SNI 2011

化学名： cis-2-Methylspiro[1,3-oxathiolane-5,3'-quinuclidine] hydrochloride

引用文献 (1)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Cevimeline hydrochloride

Cevimeline hydrochloride is a selective M₁ receptor agonist. Induces atropine-sensitive contractions of isolated guinea pig ilea and trachea preparations (EC₅₀ values are 3.5 and 3 μM respectively). Reverses AF64A-induced cognitive impairments in vivo.

技术数据 for Cevimeline hydrochloride

分子量	235.77
公式	C₁₀H₁₇NOS.HCl
储存	Store at -20°C
CAS Number	107220-28-0
PubChem ID	76965955
InChI Key	SKFLGMLYGHWKJG-RXUMEZLZSA-N
Smiles	C[C@@H](SC3)O[C@@]13CN2CCC1CC2.C[C@H](SC6)O[C@]46CN5CCC4CC5.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Cevimeline hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	17.68	75
	DMSO	11.79	50

制备储备液 for Cevimeline hydrochloride

以下数据基于产品分子量 235.77。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.75 mM	5.66 mL	28.28 mL	56.55 mL
3.75 mM	1.13 mL	5.66 mL	11.31 mL
7.5 mM	0.57 mL	2.83 mL	5.66 mL
37.5 mM	0.11 mL	0.57 mL	1.13 mL

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产品说明书 for Cevimeline hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Cevimeline hydrochloride

参考文献是支持产品生物活性的出版物。

Wanibuchi et al (1990) Pharmacological studies on novel muscarinic agonists, 1-oxa-8-azaspiro[4.5]decane derivatives, YM796 and YM954. Eur.J.Pharmacol. 187 479 PMID: 1963596

Fisher et al (1991) (+/-)-cis-2-methyl-spiro(1,3-oxathiolane-5,3')quinuclidine, an M₁ selective cholinergic agonist, attenuates cognitive dysfunctions in an animal model of Alzheimer's disease. J.Pharmacol.Exp.Ther. 257 392 PMID: 2019998

Hargreaves et al (1992) L-689,660, a novel cholinomimetic with functional selectivity for M₁ and M₃ muscarinic receptors. Br.J.Pharmacol. 107 494 PMID: 1422595

If you know of a relevant reference for Cevimeline hydrochloride, please let us know.

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关键词: Cevimeline hydrochloride, Cevimeline hydrochloride supplier, AF102B, SNI2011, selective, M1, muscarinic, cholinergic, receptors, acetylcholine, Ach, agonists, AF, 102B, SNI, 2011, Receptors, 3689, Tocris Bioscience

1 篇 Cevimeline hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Cevimeline hydrochloride 的部分引用包括：

Pasko et al (2020) Muscarinic M1 Receptors Modulate Working Memory Performance and Activity via KCNQ Potassium Channels in the Primate Prefrontal Cortex. Neuron 106 649-661.e4 PMID: 32197063

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