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说明： Non-competitive AMPA antagonist
化学名： 1-(4'-Aminophenyl)-3,5-dihydro-7,8-dimethoxy-4H-2,3-benzodiazepin-4-one
纯度： ≥98% (HPLC)
生物活性 for CFM-2
CFM-2 is a novel, selective non-competitive AMPA antagonist. Highly potent, long-acting anticonvulsant.
技术数据 for CFM-2
| 分子量 | 311.34 |
| 公式 | C17H17N3O3 |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 178616-26-7 |
| PubChem ID | 4377504 |
| InChI Key | MJKADKZSYQWGLL-UHFFFAOYSA-N |
| Smiles | COC1=CC2=C(C=C1OC)C(=NNC(=O)C2)C1=CC=C(N)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for CFM-2
参考文献 for CFM-2
参考文献是支持产品生物活性的出版物。
Chimirri et al (1997) 1-Aryl-3,5-dihydro-4H-2,3-benzodiazepin-4-ones: novel AMPA receptor antagonists. J.Med.Chem. 40 1258 PMID: 9111300
De Sarro et al (1999) Effects of some AMPA receptor antagonists on the development of tolerance in epilepsy-prone rats and in pentylenetetrazole kindled rats. Eur.J.Pharmacol. 368 149 PMID: 10193651
De Sarro et al (1999) Anticonvulsant activity and plasma level of 2,3-benzodiazepin-4-ones (CFMs) in genetically epilepsy-prone rats. Pharmacol.Biochem.Behav. 63 621 PMID: 10462191
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关键词: CFM-2, CFM-2 supplier, Non-competitive, AMPA, antagonists, Glutamate, Receptors, iGlur, Ionotropic, 1082, Tocris Bioscience
4 篇 CFM-2 的引用文献
引用文献是使用了 Tocris 产品的出版物。 CFM-2 的部分引用包括：
Park et al (2009) Role of spinal cord alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors in complete Freund's adjuvant-induced inflammatory pain. Mol Pain 4 67 PMID: 19116032
Park et al (2016) Involvement of AMPA Receptor and Its Flip and Flop Isoforms in Retinal Ganglion Cell Death Following Oxygen/Glucose Deprivation. Invest Ophthalmol Vis Sci 57 508 PMID: 26868754
Nygaard et al (2015) Melanoma brain colonization involves the emergence of a brain-adaptive phenotype. Proc Natl Acad Sci U S A 1 82 PMID: 25593989
Rzeski et al (2001) Glutamate antagonists limit tumor growth. J Pharmacol Exp Ther 98 6372 PMID: 11331750
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