CFTR_inh 172

Cat. No. 3430 12 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Voltage-independent, selective CFTR chloride channel blocker

化学名： 4-[[4-Oxo-2-thioxo-3-[3-trifluoromethyl)phenyl]-5-thiazolidinylidene]methyl]benzoic acid

纯度： ≥98% (HPLC)

引用文献 (12)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for CFTR_inh 172

CFTR_inh 172 is a voltage-independent, selective CFTR chloride channel blocker (K_i = 300 nM) that alters channel gating. Blocks intestinal fluid secretion induced by cholera toxin and Escherichia coli and suppresses cyst growth in animal models of polycystic kidney disease. Orally active. Inhibits mitochondrial respiration and increases reactive oxygen species (ROS) production independently of CFTR in several cell lines.

技术数据 for CFTR_inh 172

分子量	409.4
公式	C₁₈H₁₀F₃NO₃S₂
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	307510-92-5
PubChem ID	1554210
InChI Key	JIMHYXZZCWVCMI-RIYZIHGNSA-N
Smiles	O=C(N(C3=CC=CC(C(F)(F)F)=C3)C(S2)=S)\C2=C/C1=CC=C(C(O)=O)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for CFTR_inh 172

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	40.94	100

制备储备液 for CFTR_inh 172

以下数据基于产品分子量 409.4。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.44 mL	12.21 mL	24.43 mL
5 mM	0.49 mL	2.44 mL	4.89 mL
10 mM	0.24 mL	1.22 mL	2.44 mL
50 mM	0.05 mL	0.24 mL	0.49 mL

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产品说明书 for CFTR_inh 172

分析证书/产品说明书

化学品安全技术说明书

参考文献 for CFTR_inh 172

参考文献是支持产品生物活性的出版物。

Ma et al (2002) Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin-induced intestinal fluid secretion. J.Clin.Invest. 110 1651 PMID: 12464670

Taddei et al (2004) Altered channel gating mechanism for CFTR inhibition by a high-affinity thiazolidinone blocker. FEBS Lett. 558 52 PMID: 14759515

Yang et al (2008) Small-molecule CFTR inhibitors slow cyst growth in polycystic kidney disease. J.Am.Soc.Nephrol. 19 1300 PMID: 18385427

Rafferty et al (2009) Rescue of functional F508del cystic fibrosis transmembrane conductance regulator by vasoactive intestinal peptide in the human nasal epithelial cell line JME/CF15. J.Pharmacol.Exp.Ther. 331 2 PMID: 19584307

Kelly et al (2010) Cystic fibrosis transmembrane regulator inhibitors CFTR_inh-172 and GlyH-101 target mitochondrial functions, independently of chloride channel inhibition. J.Pharmaco.Exp.Ther. 333 60

If you know of a relevant reference for CFTR_inh 172, please let us know.

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关键词: CFTRinh 172, CFTRinh 172 supplier, Voltage-independent, selective, CFTR, chloride, channel, blockers, Cl-, Channels, CFTRinh172, 3430, Tocris Bioscience