CGH 2466 dihydrochloride

Name: CGH 2466 dihydrochloride
Brand: Tocris Bioscience
SKU: 2344

Cat. No. 2344 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

2344 has been discontinued.

View all Non-selective Adenosine products.

说明： A₁, A_2B and A₃ antagonist and inhibitor of p38 MAPK and PDE4

化学名： 4-(3,4-Dichlorophenyl)-5-(4-pyridinyl)-2-thiazolamine dihydrochloride

纯度： ≥99% (HPLC)

说明书

引用文献 (1)

生物活性技术数据说明书参考文献

生物活性 for CGH 2466 dihydrochloride

CGH 2466 dihydrochloride is an adenosine A₁, A_2B and A₃ receptor antagonist (IC₅₀ values are 19, 21, and 80 nM respectively). Also inhibits p38 MAPK (IC₅₀ = 187 - 400 nM) and phosphodiesterase type 4D (IC₅₀ = 22 nM). Displays potent anti-inflammatory effects in vitro and in vivo. Potentially useful for asthma and chronic obstructive pulmonary disease (COPD) research.

技术数据 for CGH 2466 dihydrochloride

分子量	395.13
公式	C₁₄H₉N₃SCl₂.2HCl
储存	Desiccate at +4°C
纯度	≥99% (HPLC)
CAS Number	1177618-54-0
PubChem ID	16759176
InChI Key	WHXRCTIBFLXKFD-UHFFFAOYSA-N
Smiles	Cl.Cl.NC1=NC(=C(S1)C1=CC=NC=C1)C1=CC(Cl)=C(Cl)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for CGH 2466 dihydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for CGH 2466 dihydrochloride

参考文献是支持产品生物活性的出版物。

Trifilieff et al (2005) CGH2466, a combined adenosine receptor antagonist, p38 mitogen-activated protein kinase and phosphodiesterase type 4 inhibitor with potent in vitro and in vivo anti-inflammatory activities. Br.J.Pharmacol. 144 1002 PMID: 15685201

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1 篇 CGH 2466 dihydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 CGH 2466 dihydrochloride 的部分引用包括：

Wakisaka et al (2017) An Adenosine Receptor for Olfaction in Fish. Curr Biol 27 1437 PMID: 28502661