CGP 12177 hydrochloride

Cat. No. 1134 6 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： β₃ partial agonist. β₁/β₂ antagonist

化学名： 4-[3-[(1,1-Dimethylethyl)amino]2-hydroxypropoxy]-1,3-dihydro-2H-benzimidazol-2-one hydrochloride

引用文献 (6)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for CGP 12177 hydrochloride

CGP 12177 hydrochloride is a partial agonist at β₃-adrenoceptors. β₁- and β₂-adrenoceptor antagonist (K_i values are 0.9, 4 and 88 nM for β₁, β₂ and β₃ receptors respectively).

技术数据 for CGP 12177 hydrochloride

分子量	315.8
公式	C₁₄H₂₁N₃O₃.HCl
储存	Store at RT
CAS Number	64208-32-8
PubChem ID	11957517
InChI Key	YQVFCYCTITZLSX-UHFFFAOYSA-N
Smiles	Cl.CC(C)(C)NCC(O)COC1=CC=CC2=C1NC(=O)N2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for CGP 12177 hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	water		50

制备储备液 for CGP 12177 hydrochloride

以下数据基于产品分子量 315.8。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.5 mM	6.33 mL	31.67 mL	63.33 mL
2.5 mM	1.27 mL	6.33 mL	12.67 mL
5 mM	0.63 mL	3.17 mL	6.33 mL
25 mM	0.13 mL	0.63 mL	1.27 mL

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产品说明书 for CGP 12177 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for CGP 12177 hydrochloride

参考文献是支持产品生物活性的出版物。

Galitzky et al (1998) On the presence of a putative fourth β-adrenoceptor in human adipose tissue. TiPS 19 164 PMID: 9652187

Preitner et al (1998) Metabolic response to various β-adrenoceptor agonists in β₃-adrenoceptor knockout mice: evidence for a new β-adrenergic receptor in brown adipose tissue. Br.J.Pharmacol. 124 1684 PMID: 9756384

Staehelin et al (1983) CGP-12177. A hydrophilic beta-adrenergic receptor radioligand reveals high affinity binding of agonists to intact cells. J.Biol.Chem. 258 3496 PMID: 6131886

Strosberg and Pietri-Rouxel (1996) Function and regulation of the β₃-adrenoceptor. TiPS 17 373 PMID: 8979772

If you know of a relevant reference for CGP 12177 hydrochloride, please let us know.

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关键词: CGP 12177 hydrochloride, CGP 12177 hydrochloride supplier, β3-adrenoceptor, b3-adrenoceptor, b1-adrenoceptor, β1-adrenoceptor, α1-adrenoceptor, beta1-adrenoceptor, b2-adrenoceptor, β2-adrenoceptor, α2-adrenoceptor, beta2-adrenoceptor, partial, agonists, β1-Adrenergic, beta1-Adrenergic, b1-Adrenerg, Adrenergic, Beta-3, Receptors, 1134, Tocris Bioscience

6 篇 CGP 12177 hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 CGP 12177 hydrochloride 的部分引用包括：

Kilpatrick et al (2019) Complex Formation between VEGFR2 and the β2-Adrenoceptor. Cell Chem Biol PMID: 30956148

Suárez et al (2014) Oleoylethanolamide enhances β-adrenergic-mediated thermogenesis and white-to-brown adipocyte phenotype in epididymal white adipose tissue in rat. Dis Model Mech 7 129 PMID: 24159189

Gherbi et al (2014) Detection of the secondary, low-affinity β1 -adrenoceptor site in living cells using the fluorescent CGP 12177 derivative BODIPY-TMR-CGP. Br J Pharmacol 171 5431 PMID: 25052258

Littmann et al (2015) Recruitment of β-arrestin 1 and 2 to the β2-adrenoceptor: analysis of 65 ligands. Proc Natl Acad Sci U S A 355 183 PMID: 26306764

Gherbi et al (2015) Negative cooperativity across β1-adrenoceptor homodimers provides insights into the nature of the secondary low-affinity CGP 12177 β1-adrenoceptor binding conformation. FASEB J 29 2859 PMID: 25837585

Stoddart et al (2015) Application of BRET to monitor ligand binding to GPCRs. Nat Methods 12 661 PMID: 26030448

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