主页 / 药理学 / Enzymes / Kinases / Cyclin-Dependent Kinases (CDKs) / Non-selective CDKs / Non-selective CDK Inhibitors / CGP 60474

CGP 60474

Cat. No. 5471 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent cdk inhibitor
化学名： 3-[[4-[2-[(3-Chlorophenyl)amino]-4-pyrimidinyl]-2-pyridinyl]amino]-1-propanol
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for CGP 60474

CGP 60474 is a potent cyclin-dependent kinase (cdk) inhibitor (reported IC50 values are 3 - 80, 9.5, 13, 17 - 60, 200 and 220 nM for cdk2, cdk5, cdk9, cdk1, cdk4 and cdk7, respectively). Also inhibits PKCα in the low micromolar range. Displays reversible G1/S cell cycle arrest in U2-OS cells.

技术数据 for CGP 60474

分子量 355.82
公式 C18H18ClN5O
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 164658-13-3
PubChem ID 644215
InChI Key IYNDTACKOAXKBJ-UHFFFAOYSA-N
Smiles OCCCNC1=NC=CC(C2=NC(NC3=CC(Cl)=CC=C3)=NC=C2)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for CGP 60474

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 35.58 100
1eq. HCl 17.79 50

制备储备液 for CGP 60474

以下数据基于产品分子量 355.82。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.81 mL 14.05 mL 28.1 mL
5 mM 0.56 mL 2.81 mL 5.62 mL
10 mM 0.28 mL 1.41 mL 2.81 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

参考文献 for CGP 60474

参考文献是支持产品生物活性的出版物。

Stanetty et al (2005) Novel and efficient access to phenylamino-pyrimidine type protein kinase C inhibitors utilizing a Negishi cross-coupling strategy. J.Org.Chem. 70 5215 PMID: 15960526

Sielecki et al (2000) Cyclin-dependent kinase inhibitors: useful targets in cell cycle regulation. J.Med.Chem. 43 1 PMID: 10633033

Jorda et al (2018) How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases? J.Med.Chem. 61 9105 PMID: 30234987

If you know of a relevant reference for CGP 60474, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 Non-selective CDK Inhibitors

关键词: CGP 60474, CGP 60474 supplier, CGP60474, dual, cdk1cdk2, inhibitors, inhibits, cyclin, dependent, protein, kinases, Cyclin-dependent, Kinase, Non-selective, CDKs, 5471, Tocris Bioscience

1 篇 CGP 60474 的引用文献

引用文献是使用了 Tocris 产品的出版物。 CGP 60474 的部分引用包括：

Jorda et al (2018) How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases? J.Med.Chem. 61 9105 PMID: 30234987

您是否知道使用了 Tocris CGP 60474 的优秀论文？ 请告知我们.

CGP 60474 的评论

目前没有该产品的评论。 Be the first to review CGP 60474 and earn rewards!

Have you used CGP 60474?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review