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Submit ReviewCGS 20625
说明： Selective benzodiazepine partial agonist
化学名： 5,6,7,8,9,10-Hexahydro-2-(4-methoxyphenyl)cyclohepta[b]pyrazolo[3,4-d]pyridin-3(2H)-one
纯度： ≥99% (HPLC)
生物活性 for CGS 20625
CGS 20625 is a selective, partial agonist for the benzodiazepine binding site of the GABAA receptor. Potently inhibits [3H]-flunitrazepam binding to central benzodiazepine receptors (IC50 = 1.3 nM) and displays weak affinity for peripheral benzodiazepine (IC50 = 0.68 - 2.25 μM) and GABA binding sites (IC50 > 10000 μM). Displays anxiolytic activity in vivo following oral administration..
技术数据 for CGS 20625
| 分子量 | 309.36 |
| 公式 | C18H19N3O2 |
| 储存 | Store at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 111205-55-1 |
| PubChem ID | 163844 |
| InChI Key | UBLXQFIFWUEVGJ-UHFFFAOYSA-N |
| Smiles | COC1=CC=C(C=C1)N1N=C2C(=CNC3=C2CCCCC3)C1=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for CGS 20625
参考文献 for CGS 20625
参考文献是支持产品生物活性的出版物。
Bennett (1987) Pharmacology of the pyrazolo-type compounds: agonist, antagonist and inverse agonist actions. Physiol.Behav. 41 241 PMID: 2893398
Williams et al (1989) CGS 20625, a novel pyrazolopyridine anxiolytic. J.Pharmacol.Exp.Ther. 248 89 PMID: 2563294
Jarvis et al (1990) CGS 20625, a novel pyrazolopyridine with selective anxiolytic activity. Prog.Clin.Biol.Res. 361 477 PMID: 1981266
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关键词: CGS 20625, CGS 20625 supplier, Selective, central, benzodiazepine, receptor, partial, agonists, GABAA, Receptors, CGS20625, 2467, Tocris Bioscience
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