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Submit ReviewChemerin-9, Human
说明： Potent CMKLR1 agonist; c-terminal peptide of full length human chemerin
纯度： ≥95% (HPLC)
生物活性 for Chemerin-9, Human
Chemerin-9, Human is a potent chemokine-like receptor 1 (CMKLR1; also known as chemerin receptor 23, ChemR23) agonist (EC50 = 7.1 nM at CMKLR expressed in CHO cells). Corresponds to C-terminal of full length human Chemerin, amino acids 149 - 157. Activates Gi/o signaling pathways in vitro; inhibits cAMP production and promotes phospholipase C production and Ca2+ mobilization.
技术数据 for Chemerin-9, Human
| 分子量 | 1063.18 |
| 公式 | C54H66N10O13 |
| 序列 | YFPGQFAFS |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 676367-27-4 |
| PubChem ID | 11332190 |
| InChI Key | QLVGSBXIQFERFK-NBBYSTNSSA-N |
| Smiles | O=C(N[C@@H](CC1=CC=CC=C1)C(N2[C@@H](CCC2)C(NCC(N[C@@H](CCC(N)=O)C(N[C@@H](CC3=CC=CC=C3)C(N[C@@H](C)C(N[C@@H](CC4=CC=CC=C4)C(N[C@@H](CO)C(O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC5=CC=C(C=C5)O)N |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Chemerin-9, Human
| 溶解性 | Soluble to 1 mg/ml in water |
产品说明书 for Chemerin-9, Human
参考文献 for Chemerin-9, Human
参考文献是支持产品生物活性的出版物。
Wittamer et al (2004) The C-terminal nonapeptide of mature chemerin activates the chemerin receptor with low nanomolar potency. J.Med.Chem. 279 9956 PMID: 14701797
De Henau et al (2016) Signaling properties of chemerin receptors CMKLR1, GPR1 and CCRL2. PLoS One. 11 PMID: 27716822
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关键词: Chemerin-9, Human, Chemerin-9, Human supplier, chemerin, 9, chemokine, like, receptor, 1, 23, ChemR23, CMKLR1, agonists, agonism, 149, -, 157, human, Other, Chemokine, Receptors, 7116, Tocris Bioscience
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