Chlorisondamine diiodide

Name: Chlorisondamine diiodide
Brand: Tocris Bioscience
SKU: 1001

Cat. No. 1001 4 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

1001 has been discontinued.

View all Nicotinic Receptors (Non-selective) products.

说明： nAChR antagonist; slow offset

别名： 3-[[4-(Chlorophenyl)piperazin-1-yl]methyl-1H-pyrrolo[2,3-b]pyridine diiodide

化学名： 4,5,6,7-Tetrachloro-1,3-dihydro-2-methyl-2-[2-trimethylammonium)ethyl]-2H-isoindolium diiodide

纯度： ≥99% (HPLC)

说明书

引用文献 (4)

文献 (1)

生物活性技术数据说明书参考文献

生物活性 for Chlorisondamine diiodide

An exceptionally long lasting nicotinic antagonist (IC₅₀ ~ 1.6 mM); blockade of central nicotinic responses induced by chlorisondamine can persist for several weeks.

技术数据 for Chlorisondamine diiodide

分子量	611.95
公式	C₁₄H₂₀Cl₄I₂N₂
储存	Desiccate at +4°C
纯度	≥99% (HPLC)
CAS Number	96750-66-2
PubChem ID	16078959
InChI Key	FPNVAOZHQUJJJQ-UHFFFAOYSA-L
Smiles	[I-].[I-].C[N+](C)(C)CC[N+]1(C)CC2=C(Cl)C(Cl)=C(Cl)C(Cl)=C2C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Chlorisondamine diiodide

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Chlorisondamine diiodide

参考文献是支持产品生物活性的出版物。

Clarke et al (1994) The pharmacology of the nicotinic antagonist, chlorisondamine investigated in rat brain and autonomic ganglion. Br.J.Pharmacol. 111 397 PMID: 7911713

El-Bizri and Clarke (1994) Blockade of nicotinic receptor-mediated release of DA from striatal synaptosomes by chlorisondamine and other nicotinic antagonists administered in vitro. Br.J.Pharmacol. 111 406 PMID: 8004384

El-Bizri and Clarke (1994) Regulation of nicotinic receptors in rat brain following quasi-irreversible nicotinic blockade by chlorisondamine and chronic treatment with nicotine. Br.J.Pharmacol. 113 917 PMID: 7858886

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关键词: Chlorisondamine diiodide, Chlorisondamine diiodide supplier, Nicotinic, antagonists, slow, offset, Acetylcholine, Receptors, Non-Selective, nAChR, 3-[[4-(Chlorophenyl)piperazin-1-yl]methyl-1H-pyrrolo[2,3-b]pyridine, diiodide, (Non-selective), 1001, Tocris Bioscience

4 篇 Chlorisondamine diiodide 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Chlorisondamine diiodide 的部分引用包括：

Luyer et al (2005) Nutritional stimulation of cholecystokinin receptors inhibits inflammation via the vagus nerve. Clin Sci (Lond) 202 1023 PMID: 16216887

Sabharwal et al (2014) Chronic oral administration of Ang-(1-7) improves skeletal muscle, autonomic and locomotor phenotypes in muscular dystrophy. J Cereb Blood Flow Metab 127 101 PMID: 24502705

Sabharwal et al (2015) Angiotensin-dependent autonomic dysregulation precedes dilated cardiomyopathy in a mouse model of muscular dystrophy. J Exp Med 100 776 PMID: 25921929

Bucci et al (2013) Cross-talk between toll-like receptor 4 (TLR4) and proteinase-activated receptor 2 (PAR(2) ) is involved in vascular function. Br J Pharmacol 168 411 PMID: 22957757