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Submit ReviewChlormethiazole hydrochloride is a sedative and anticonvulsant which is neuroprotective in a number of animal models. Prevents the degeneration of serotonergic nerve terminals induced by MDMA ('Ecstasy').
分子量 | 198.11 |
公式 | C6H8ClNS.HCl |
储存 | Desiccate at RT |
纯度 | ≥99% (HPLC) |
CAS Number | 6001-74-7 |
PubChem ID | 19035073 |
InChI Key | OFXYKSLKNMTBHK-UHFFFAOYSA-N |
Smiles | ClCCC1=C(C)N=CS1.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
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参考文献是支持产品生物活性的出版物。
Cross et al (1995) The protective action of chloromethiazole against ischaemia induced neurodegeneration in gerbils when infused at doses having little sedative or anticonvulsant activity. Br.J.Pharmacol. 114 1625 PMID: 7599932
Hewitt and Green (1994) Chloromethiazole, dizocilpine and halope. prevent the degeneration of serotonergic nerve terminals induced by the administration of MDMA ('Ecstasy') to rats. Neuropharmacology 33 1589 PMID: 7539115
关键词: Chlormethiazole hydrochloride, Chlormethiazole hydrochloride supplier, Potentiates, GABAA, receptor, function, Receptors, modulators, 0881, Tocris Bioscience
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Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.
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