Chloroquine diphosphate

Cat. No. 4109 13 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Antimalarial; inhibits apoptosis and autophagy

化学名： N⁴-(7-Chloro-4-quinolinyl)-N¹,N¹-dimethyl-1,4-pentanediamine diphosphate salt

纯度： ≥99% (HPLC)

引用文献 (13)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Chloroquine diphosphate

Chloroquine diphosphate is an antimalarial (Plasmodium) medicine. Inhibits cell growth and induces cell death in numerous cancer cell lines; inhibits cell proliferation and viability and induces apoptosis in 4T1 mouse breast cancer cells in vitro. Exhibits antimetastatic activity. Also inhibits autophagy via a mechanism distinct from that of 3-methyladenine (Cat. No. 3977). Blocks receptor-mediated endocytosis of mannose-glycoconjugates by macrophages. Inhibits SARS-CoV-2 infection in vitro (EC₅₀ = 1.13 μM). Chloroquine improves efficacy of adeno-associated viral gene transduction in vivo and in vitro, as well as enhancing non-viral gene transfection in breast cancer cells.

Tocris products are for biomedical research use only. They are not intended for human or veterinary use.

技术数据 for Chloroquine diphosphate

分子量	515.86
公式	C₁₈H₂₆ClN₃·2H₃PO₄
储存	Desiccate at RT
纯度	≥99% (HPLC)
CAS Number	50-63-5
PubChem ID	64927
InChI Key	QKICWELGRMTQCR-UHFFFAOYSA-N
Smiles	CCN(CC)CCCC(C)NC2=CC=NC1=CC(Cl)=CC=C12.O=P(O)(O)O.O=P(O)(O)O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Chloroquine diphosphate

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	water	51.59	100

制备储备液 for Chloroquine diphosphate

以下数据基于产品分子量 515.86。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.94 mL	9.69 mL	19.39 mL
5 mM	0.39 mL	1.94 mL	3.88 mL
10 mM	0.19 mL	0.97 mL	1.94 mL
50 mM	0.04 mL	0.19 mL	0.39 mL

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产品说明书 for Chloroquine diphosphate

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Chloroquine diphosphate

参考文献是支持产品生物活性的出版物。

Jiang et al (2010) Antitumor and antimetastatic activities of chloroquine diphosphate in a murine model of breast cancer. Biomed.Pharmacother. 64 609 PMID: 20888174

Sasaki et al (2010) Chloroquine potentiates the anti-cancer effect of 5-fluorouracil on colon cancer cells. BMC Cancer 10 370 PMID: 20630104

Wang et al (2020) Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Research 30

Tietze et al (1980) Chloroquine and ammonium ion inhibit receptor-mediated endocytosis of mannose-glycoconjugates by macrophages: Apparent inhibition of receptor recycling. Biochem.Biophys.Res.Commun. 93 1 PMID: 7378072

Chandler et al (2019) Enhancement of adeno-associated cirus-mediated gene therapy using hydroxychloroquine in murine and human tissues. Mol.Ther.Methods Clin.Dev. 14 77 PMID: 31309129

McErlean et al (2021) Rational design and characterisation of a linear cell penetrating peptide for non-viral gene delivery. J.Control.Release 330 1288 PMID: 33227336

If you know of a relevant reference for Chloroquine diphosphate, please let us know.

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