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CI 1020

Cat. No. 2942 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

2942 has been discontinued.

View all ET<sub>A</sub> Receptors products.
说明： Highly selective, orally active ETA antagonist
别名： PD 156707
化学名： 3-(1,3-Benzodioxol-5-yl)-5-hydroxy-5-(4-methoxyphenyl)-4-[(3,4,5-trimethoxyphenyl)methyl]-2(5H)-furanone
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 说明书 参考文献

生物活性 for CI 1020

CI 1020 is a highly selective, orally active, non-peptide endothelin-A receptor (ETA) antagonist (IC50 values are 0.3 and 480 nM for ETA and ETB receptors respectively). Antihypertensive; blocks ET-1-induced pressor responses following oral administration.

许可信息

Sold for research purposes under agreement from Pfizer Inc.

技术数据 for CI 1020

分子量 506.5
公式 C28H26O9
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 162256-50-0
PubChem ID 9870830
InChI Key PWIPORDFWDZCJG-UHFFFAOYSA-N
Smiles O=C1C(C2=CC=C(OCO4)C4=C2)=C(CC3=CC(OC)=C(OC)C(OC)=C3)C(O)(C5=CC=C(OC)C=C5)O1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for CI 1020

分析证书/产品说明书
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化学品安全技术说明书

参考文献 for CI 1020

参考文献是支持产品生物活性的出版物。

Doherty et al (1995) Discovery of a novel series of orally active non-peptide endothelin-A (ETA) receptor-selective antagonists. J.Med.Chem. 38 1259 PMID: 7731010

Jones et al (1999) The effect of the endothelin ETA receptor antagonist CI-1020 on hypoxic pulmonary vasoconstriction. Eur.J.Pharmacol. 374 367 PMID: 10422781

Coe et al (2002) The endothelin A receptor antagonists PD 156707 (CI-1020) and PD 180988 (CI-1034) reverse the hypoxic pulmonary vasoconstriction in ther perinatal lamb. J.Pharmacol.Exp.Ther. 302 672 PMID: 12130731

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关键词: CI 1020, CI 1020 supplier, selective, orally, active, ETA, antagonists, Receptors, Endothelin, CI1020, Pfizer, PD156707, PD, 156707, 2942, Tocris Bioscience

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