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说明： Caged inositol triphosphate
化学名： 6-O-[(4,5-Dimethoxy-2-nitrophenyl)methyl]-2,3-O-(1-methylethylidene)-D-myo-Inositol 1,4,5-tris[bis[(1-oxopropoxy)methyl]phosphate]
纯度： ≥98% (HPLC)
生物活性 for ci-IP3/PM
ci-IP3/PM is a caged inositol triphosphate. Cell permeable. UV photolysis (λ = 330 nm) in HeLa cells releases i-IP3, promoting Ca2+-release from internal stores.
F 127 (Cat. No. 6253) for the solubilization of ci-IP3/PM is also available.
技术数据 for ci-IP3/PM
| 分子量 | 1171.87 |
| 公式 | C42H64NO31P3 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1009832-82-9 |
| PubChem ID | 124221754 |
| InChI Key | FNWIHZJMPHUCAI-RJQNPCEJSA-N |
| Smiles | CC(O1)(C)O[C@H]([C@H]1[C@@H](OP(OCOC(CC)=O)(OCOC(CC)=O)=O)[C@@H]2OP(OCOC(CC)=O)(OCOC(CC)=O)=O)[C@@H](OP(OCOC(CC)=O)(OCOC(CC)=O)=O)[C@@H]2OCC3=CC(OC)=C(OC)C=C3[N+]([O-])=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for ci-IP3/PM
| 溶解性 | Soluble in DMSO |
产品说明书 for ci-IP3/PM
参考文献 for ci-IP3/PM
参考文献是支持产品生物活性的出版物。
Dakin and Li et al (2007) Cell membrane permeable esters of D-myo-inositol 1,4,5-trisphosphate. Cell Calcium 42 291 PMID: 17307252
Lock et al (2017) Comparison of Ca2+ puffs evoked by extracellular agonists and photoreleased IP3. Cell Calcium PMID: 28108028
Zhang et al (2004) Endothelin-1 and IP3 induced Ca2+ sparks in pulmonary arterial smooth muscle cells. J.Cardiovasc.Pharmacol. 44 S121 PMID: 15838259
If you know of a relevant reference for ci-IP3/PM, please let us know.
关键词: ci-IP3/PM, ci-IP3/PM supplier, Caged, IP3, activated, intracellular, Ca2+, calcium, stores, photolysis, UV, inositol, triphosphate, Second, Messenger, Compounds, Receptors, 6210, Tocris Bioscience
9 篇 ci-IP3/PM 的引用文献
引用文献是使用了 Tocris 产品的出版物。 ci-IP3/PM 的部分引用包括：
Sundeep et al (2021) CREB regulates the expression of type 1 inositol 1,4,5-trisphosphate receptors. J Cell Sci 134 PMID: 34533188
David I et al (2021) Omnitemporal choreographies of all five STIM/Orai and IP3Rs underlie the complexity of mammalian Ca2+ signaling. Cell Rep 34 108760 PMID: 33657364
David I et al (2021) A protocol for detecting elemental calcium signals (Ca2+ puffs) in mammalian cells using total internal reflection fluorescence microscopy. STAR Protoc 2 100618 PMID: 34195673
David I et al (2021) The Mitochondrial Ca2+ uniporter is a central regulator of interorganellar Ca2+ transfer and NFAT activation. J Biol Chem 297 101174 PMID: 34499925
Jonathan et al (2023) Disruption of Mitochondrial-associated ER membranes by HIV-1 tat protein contributes to premature brain aging. CNS Neurosci Ther 29 365-377 PMID: 36419337
Tiziano et al (2023) Pharmacological potentiators of the calcium signaling cascade identified by high-throughput screening. PNAS Nexus 2 pgac288 PMID: 36712939
Sundeep et al (2022) Functional determination of calcium-binding sites required for the activation of inositol 1,4,5-trisphosphate receptors. Proc Natl Acad Sci U S A 119 e2209267119 PMID: 36122240
Yu et al (2022) Segregated cation flux by TPC2 biases Ca2+ signaling through lysosomes. Nat Commun 13 4481 PMID: 35918320
Vinu et al (2020) Fluoride exposure alters Ca2+ signaling and mitochondrial function in enamel cells. Sci Signal 13 PMID: 32071168
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