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CIA 1

Cat. No. 7494 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： COUP-TFII inhibitor
化学名： N-[2-(3,4-Dimethoxyphenyl)ethyl]-6-methylthieno[2,3-d]pyrimidin-4-amine hydrochloride
纯度： ≥98% (HPLC)
说明书
引用文献
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生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for CIA 1

CIA 1 is an inhibitor of the nuclear receptor COUP-TFII (IC50 ranged from 1.2 μM to 7.6 μM, in prostate cancer cell lines). In vitro, CIA 1 inhibits growth of multiple prostate cancer cell lines and suppresses COUP-TFII activity to regulate its target genes. In vivo, CIA 1 reduces tumor growth in prostate cancer xenograft mouse models.

技术数据 for CIA 1

分子量 365.88
公式 C17H19N3O2S.HCl
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1049691-47-5
PubChem ID 2974648
InChI Key PYRMFONFWQTEGD-UHFFFAOYSA-N
Smiles COC1=C(C=C(C=C1)CCNC2=C3C=C(SC3=NC=N2)C)OC.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for CIA 1

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 7.32 20

制备储备液 for CIA 1

以下数据基于产品分子量 365.88。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.2 mM 13.67 mL 68.33 mL 136.66 mL
1 mM 2.73 mL 13.67 mL 27.33 mL
2 mM 1.37 mL 6.83 mL 13.67 mL
10 mM 0.27 mL 1.37 mL 2.73 mL

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参考文献 for CIA 1

参考文献是支持产品生物活性的出版物。

Wang et al (2020) Small-molecule inhibitor targeting orphan nuclear receptor COUP-TFII for prostate cancer treatment. Sci.Adv. 6 eaaz8031 PMID: 32494682

If you know of a relevant reference for CIA 1, please let us know.

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关键词: CIA 1, CIA 1 supplier, inhibitors, inhibits, COUP, TFII, nuclear, receptor, prostate, cancer, NR2F2, TFCOUP2, Other, Nuclear, Receptors, 7494, Tocris Bioscience

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