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Submit ReviewCinalukast
Discontinued Product
2025 has been discontinued.
View all Leukotriene and Related Receptors products.
说明： Potent, selective CysLT1 (LTD4) antagonist; orally active
别名： Ro 24-5913
化学名： 4-[[3-[(1E)-2-(4-Cyclobutyl-2-thiazolyl)ethenyl]phenyl]amino]-2,2-diethyl-4-oxobutanoic acid
纯度： ≥98% (HPLC)
生物活性 for Cinalukast
Potent, selective CysLT1 (LTD4) leukotriene receptor antagonist (IC50 = 6.4 nM). Inhibits LTD4-induced bronchoconstriction in guinea pigs when administered intravenously, orally or by aerosol.
技术数据 for Cinalukast
| 分子量 | 412.55 |
| 公式 | C23H28N2O3S |
| 储存 | Desiccate at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 128312-51-6 |
| PubChem ID | 6436135 |
| InChI Key | BZMKNPGKXJAIDV-VAWYXSNFSA-N |
| Smiles | CCC(CC)(CC(=O)NC1=CC(\C=C\C2=NC(=CS2)C2CCC2)=CC=C1)C(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Cinalukast
参考文献 for Cinalukast
参考文献是支持产品生物活性的出版物。
O'Donnell (1991) Ro 24-5913: a potent, specific, orally active LTD4 antagonist. Ann.N.Y.Acad.Sci. 629 413 PMID: 1659286
O'Donnell et al (1991) Pharmacologic actions of Ro 24-5913, a novel antagonist of leukotriene D4. J.Pharmacol.Exp.Ther. 259 751 PMID: 1658310
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关键词: Cinalukast, Cinalukast supplier, Potent, selective, CysLT1, LTD4, antagonists, orally, active, Receptors, LTE4, leukotrienes, eicosanoids, Ro245913, Ro, 24-5913, Leukotriene, and, Related, 2025, Tocris Bioscience
1 篇 Cinalukast 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Cinalukast 的部分引用包括：
Wright et al (2019) Pranlukast is a novel small molecule activator of the two-pore domain potassium channel TREK2. Biochem Biophys Res Commun 520 35 PMID: 31564414
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