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Submit ReviewCinnabarinic acid
Discontinued Product
4119 has been discontinued.
View all Glutamate (Metabotropic) Group III Receptors products.
说明： Selective mGlu4 agonist
化学名： 2-Amino-3-oxo-3H-phenoxazine-1,9-dicarboxylic acid
纯度： ≥98% (HPLC)
生物活性 for Cinnabarinic acid
Cinnabarinic acid is a mGlu4 receptor agonist. Activates mGlu4 receptors in transiently transfected HEK293 cells; selective over all other mGlu subtypes (mGlu1, mGlu2 and mGlu5-8). Decreases cAMP levels in native cultured cerebellar granule cells. Also counteracts excitotoxic neuronal cell death induced by NMDA in mixed cultures of cortical cells; displays neuroprotective activity.
技术数据 for Cinnabarinic acid
| 分子量 | 300.22 |
| 公式 | C14H8N2O6 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 606-59-7 |
| PubChem ID | 114918 |
| InChI Key | FSBKJYLVDRVPTK-UHFFFAOYSA-N |
| Smiles | O=C2C(N)=C(C(O)=O)C1=NC3=C(C=CC=C3C(O)=O)OC1=C2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Cinnabarinic acid
参考文献 for Cinnabarinic acid
参考文献是支持产品生物活性的出版物。
Fazio (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type-4 metabotropic glutamate receptors. Mol.Pharmacol. Feb 6 Epub ahead of print PMID: 22311707
关键词: Cinnabarinic acid, Cinnabarinic acid supplier, metabotropic, glutamate, mglu4, agonists, selective, Glutamate, (Metabotropic), Group, III, Receptors, 4119, Tocris Bioscience
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Metabotropic Glutamate Receptors Scientific Review
Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.
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