Cirazoline hydrochloride

Cat. No. 0888 4 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Selective α₁ agonist

化学名： 2-(2-Cyclopropylphenoxymethyl)imidazoline hydrochloride

纯度： ≥99% (HPLC)

引用文献 (4)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Cirazoline hydrochloride

Cirazoline hydrochloride is a selective α₁ agonist.

技术数据 for Cirazoline hydrochloride

分子量	252.74
公式	C₁₃H₁₆N₂O.HCl
储存	Store at RT
纯度	≥99% (HPLC)
CAS Number	40600-13-3
PubChem ID	11957512
InChI Key	XFRXWLWUUDJHPB-UHFFFAOYSA-N
Smiles	Cl.C(OC1=C(C=CC=C1)C1CC1)C1=NCCN1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Cirazoline hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	25.27	100
	DMSO	25.27	100

制备储备液 for Cirazoline hydrochloride

以下数据基于产品分子量 252.74。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	3.96 mL	19.78 mL	39.57 mL
5 mM	0.79 mL	3.96 mL	7.91 mL
10 mM	0.4 mL	1.98 mL	3.96 mL
50 mM	0.08 mL	0.4 mL	0.79 mL

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产品说明书 for Cirazoline hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Cirazoline hydrochloride

参考文献是支持产品生物活性的出版物。

Le Rouzic et al (1995) Binding of [³H]cirazoline to an imidazoline site in rat brain and kidney membranes. Eur.J.Pharmacol. 278 261 PMID: 7589165

Gellai and Ruffolo (1987) Renal effects of selective alpha-1 and alpha-2 adrenoreceptor agonists in conscious normotensive rats. J.Pharmacol.Exp.Ther. 240 723 PMID: 2882013

Wikberg and Uklen (1990) Further characterisation of the guinea pig cerebral cortex idazoxan receptor: solubilization, distinction from the imidazole site, and demonstration of cirazoline as an idazoxan receptor-selective drug. J.Neurochem. 55 192 PMID: 1972387

If you know of a relevant reference for Cirazoline hydrochloride, please let us know.

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4 篇 Cirazoline hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Cirazoline hydrochloride 的部分引用包括：

Kahn et al (2016) The anti-hypertensive drug pra. inhibits glioblastoma growth via the PKCδ-dependent inhibition of the AKT pathway. EMBO Mol Med 8 511 PMID: 27138566

Bhattachariya et al (2014) PYK2 selectively mediates signals for growth versus differentiation in response to stretch of spontaneously active vascular smooth muscle. Physiol Rep 2 PMID: 25347863

Montgomery (2017) An Alpha-1A Adrenergic Receptor Agonist Prevents Acute dox. Cardiomyopathy in Male Mice. Plos One 12 e0168409 PMID: 28081170

Maupoil et al (2007) Ectopic activity in the rat pulmonary vein can arise from simultaneous activation of alpha1- and beta1-adrenoceptors. Br J Pharmacol 150 899 PMID: 17325650

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