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说明： Potent, selective L-glutamate uptake inhibitor
化学名： cis-1-Aminocyclobutane-1,3-dicarboxylic acid
生物活性 for cis-ACBD
cis-ACBD is a potent, competitive and selective inhibitor of glutamate uptake. Certain confusion exists over the naming of this compound because of apparent contradictions in the literature. This is the isomer which has the carboxylic acid and the amino groups on the same side of the cyclobutyl ring.
技术数据 for cis-ACBD
| 分子量 | 159.14 |
| 公式 | C6H9NO4 |
| 储存 | Store at RT |
| CAS Number | 73550-55-7 |
| PubChem ID | 1214 |
| InChI Key | GGMYWPBNZXRMME-UHFFFAOYSA-N |
| Smiles | [H][C@@]1([C@@](O)=O)C[C@@](N)([C@](O)=O)C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for cis-ACBD
参考文献 for cis-ACBD
参考文献是支持产品生物活性的出版物。
Allan et al (1990) Synthesis and activity of a potent NMDA agonist, trans-1-aminocyclobutane-1,3-dicarboxylic acid, and related phosphonic and carboxylic acids. J.Med.Chem. 33 2905 PMID: 2145435
Fletcher et al (1991) Inhibition of L-glutamic acid uptake into rat cortical synaptosomes by the conformationally restricted analogue of glutamic acid, cis-1-aminocyclobutane-1,3-dicarboxylic acid. Neurosci.Lett. 121 133 PMID: 1673544
Koch et al (1999) Differentiation of substrate and nonsubstrate inhibitors of the high-affinity, sodium-dependent glutamate transporters. Mol.Pharmacol. 56 1095 PMID: 10570036
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关键词: cis-ACBD, cis-ACBD supplier, Potent, selective, competitive, L-glutamate, uptake, inhibitors, inhibits, EAAT, Excitatory, Amino, Acid, Transporters, GLAST, GLT-1, Glutamate, Monoamine, Neurotransmitter, 0271, Tocris Bioscience
1 篇 cis-ACBD 的引用文献
引用文献是使用了 Tocris 产品的出版物。 cis-ACBD 的部分引用包括：
Lee et al (2010) Characterisation of the expression of NMDA receptors in human astrocytes. PLoS One 5 e14123 PMID: 21152063
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Huntington's Disease Poster
Huntington's disease (HD) is a severe monogenic neurodegenerative disorder, which is characterized by the prevalent loss of GABAergic medium spiny neurons (MSN) in the striatum. This poster summarizes the effects of mutant huntingtin aggregation implicated in the pathology of HD, as well as highlighting the use of iPSCs for HD modeling.