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Submit ReviewSelective NMDA receptor agonist. Positive modulator of NMDA receptor at low (<50μM) concentrations, exhibits glutamate-like agonist activity at higher concentrations.
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分子量 | 145.11 |
储存 | Store at RT |
CAS Number | 121050-04-2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
参考文献是支持产品生物活性的出版物。
Kozikowski et al (1990) Synthesis and bioactivity of a new class of rigid glutamate analogues. Modulators of the N-MthD.-aspartate receptor. J.Med.Chem. 33 1561 PMID: 2160533
关键词: cis-Azetidine-2,4-dicarboxylic acid, cis-Azetidine-2,4-dicarboxylic acid supplier, NMDA, Receptors, 0859, Tocris Bioscience
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意,Tocris 仅会向正规科研企业/机构地址发送文献。
This product guide provides a background to Huntington's disease research and lists around 100 products for the study of:
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Huntington's disease (HD) is a severe monogenic neurodegenerative disorder, which is characterized by the prevalent loss of GABAergic medium spiny neurons (MSN) in the striatum. This poster summarizes the effects of mutant huntingtin aggregation implicated in the pathology of HD, as well as highlighting the use of iPSCs for HD modeling.
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.