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cis VH 032, amine dihydrochloride

Cat. No. 6969 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Negative control for VH 032, amine (Cat. No. 6462)
别名： (S,S,S)-AHPC
化学名： (2S,4S)-1-[(2S)-2-Amino-3,3-dimethyl-butanoyl]-4-hydroxy-N-[[4-(4-methylthiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide dihydrochloride
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
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文献 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for cis VH 032, amine dihydrochloride

cis VH 032, amine dihydrochloride is a negative control for the functionalized VHL ligand VH 032, amine (Cat. No. 6462).

Usage Guidelines for cis VH 032, amine dihydrochloride

This product is provided for use in onward chemistry. Suitable solvents can be used.

技术数据 for cis VH 032, amine dihydrochloride

分子量 503.48
公式 C22H30N4O3S.2HCl
储存 Desiccate at RT
纯度 ≥98% (HPLC)
CAS Number 2376990-32-6
Smiles CC1=C(C2=CC=C(C=C2)CNC([C@@H]3C[C@@H](CN3C([C@H](C(C)(C)C)N)=O)O)=O)SC=N1.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for cis VH 032, amine dihydrochloride

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参考文献 for cis VH 032, amine dihydrochloride

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1 篇 cis VH 032, amine dihydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 cis VH 032, amine dihydrochloride 的部分引用包括：

Smalley et al (2020) PROTAC-mediated degradation of class I histone deacetylase enzymes in corepressor complexes. Chem.Commun.(Camb) 56 4476 PMID: 32201871

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Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia