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CL 075

Cat. No. 6142 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

6142 has been discontinued.

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说明： TLR8 agonist
化学名： 2-Propylthiazolo[4,5-c]quinolin-4-amine
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
通路 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for CL 075

CL 075 is a TLR8 agonist. Induces production of TNF-α and IL-12 from peripheral blood mononuclear cells (PBMCs). Promotes maturation of monocyte-derived dendritic cells in combination with Poly(I:C) (Cat. No. 4287).

技术数据 for CL 075

分子量 243.33
公式 C13H13N3S
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 256922-53-9
PubChem ID 10198719
InChI Key NFYMGJSUKCDVJR-UHFFFAOYSA-N
Smiles CCCC1=NC2=C(N=C3C=CC=CC3=C2S1)N

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for CL 075

参考文献是支持产品生物活性的出版物。

Gorden et al (2005) Synthetic TLR agonists reveal functional differences between human TLR7 and TLR8. J.Immunol. 174 1259 PMID: 15661881

Pang et al (2011) Inhibition of TLR8- and TLR4-induced Type I IFN induction by alcohol is different from its effects on inflammatory cytokine production in monocytes. BMC Immunol. 12 55 PMID: 21962237

Spranger et al (2010) Generation of Th1-polarizing dendritic cells using the TLR7/8 agonist CL075. J.Immunol. 185 738 PMID: 20511554

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关键词: CL 075, CL 075 supplier, CL075, Toll-like, receptors, TLR8, agonists, agonism, Receptors, 6142, Tocris Bioscience

1 篇 CL 075 的引用文献

引用文献是使用了 Tocris 产品的出版物。 CL 075 的部分引用包括：

Mathieu et al (2019) The Mitochondrial Transacylase, Tafazzin, Regulates for AML Stemness by Modulating Intracellular Levels of Phospholipids. Cell Stem Cell 24 621-636.e16 PMID: 30930145

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Pathways for CL 075

Toll-like Receptor Signaling Pathway

Toll-like Receptor Signaling Pathway

TLR signaling is involved in the cellular response to threatening molecules such as bacteria and viruses. It results in an inflammatory and immmunological response.