Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewCL 218872
说明： Benzodiazepine agonist
化学名： 3-Methyl-6-[-3-(trifluoromethyl)phenyl]-1,2,4-triazolo[4,3-b]pyridazine
纯度： ≥98% (HPLC)
生物活性 for CL 218872
CL 218872 is a benzodiazepine agonist displaying selectivity for α1 subunit-containing GABAA receptors (Ki values are 130, 1820, 1530, > 10000, 490 and > 10000 nM for α1, α2, α3, α4, α5 and α6-subunit containing receptors respectively). Orally active anxiolytic and anticonvulsant in vivo.
技术数据 for CL 218872
| 分子量 | 278.24 |
| 公式 | C13H9F3N4 |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 66548-69-4 |
| PubChem ID | 107950 |
| InChI Key | GUOQUXNJZHGPQF-UHFFFAOYSA-N |
| Smiles | CC1=NN=C2C=CC(=NN12)C1=CC(=CC=C1)C(F)(F)F |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for CL 218872
参考文献 for CL 218872
参考文献是支持产品生物活性的出版物。
Lippa et al (1979) Benzodiazepine receptors: cellular and behavioral characteristics. Pharmacol.Biochem.Behav. 10 831 PMID: 40258
Sieghart (1995) Structure and pharmacology of γ-aminobutyric acidA receptor subtypes. Pharmacol.Rev. 47 181 PMID: 7568326
Squires et al (1979) Some properties of brain specific benzodiazepine receptors: new evidence for multiple receptors. Pharmacol.Biochem.Behav. 10 825 PMID: 40257
按产品操作查看相关产品
关键词: CL 218872, CL 218872 supplier, Benzodiazepine, agonists, GABAA, Receptors, CL218872, 1709, Tocris Bioscience
1 篇 CL 218872 的引用文献
引用文献是使用了 Tocris 产品的出版物。 CL 218872 的部分引用包括：
Wang et al (2018) Contribution of the α5 GABAA receptor to the discriminative stimulus effects of PROP in rat. Neuroreport 29 347 PMID: 29369902
CL 218872 的评论
目前没有该产品的评论。 Be the first to review CL 218872 and earn rewards!
Have you used CL 218872?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
GABA Receptors Scientific Review
Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.
Addiction Poster
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.