CL 316243 disodium salt

Cat. No. 1499 21 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Highly selective β₃ agonist

化学名： 5-[(2R)-2-[[(2R)-2-(3-Chlorophenyl)-2-hydroxyethyl]amino]propyl]-1,3-benzodioxole-2,2-dicarboxylic acid disodium salt

纯度： ≥97% (HPLC)

引用文献 (21)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for CL 316243 disodium salt

CL 316243 disodium salt is a potent and highly selective β₃-adrenoceptor agonist (EC₅₀ = 3 nM); > 10000-fold selective over β₁ and β₂ receptors. Increases brown adipose tissue thermogenesis and metabolic rate, and decreases blood insulin and glucose levels following oral administration in vivo.

技术数据 for CL 316243 disodium salt

分子量	465.8
公式	C₂₀H₁₈ClNNa₂O₇
储存	Store at -20°C
纯度	≥97% (HPLC)
CAS Number	138908-40-4
PubChem ID	5312115
InChI Key	FUZBPOHHSBDTJQ-CFOQQKEYSA-L
Smiles	[Na+].[Na+].C[C@H](CC1=CC=C2OC(OC2=C1)(C([O-])=O)C([O-])=O)NC[C@H](O)C1=CC=CC(Cl)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for CL 316243 disodium salt

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	water	46.58	100

制备储备液 for CL 316243 disodium salt

以下数据基于产品分子量 465.8。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.15 mL	10.73 mL	21.47 mL
5 mM	0.43 mL	2.15 mL	4.29 mL
10 mM	0.21 mL	1.07 mL	2.15 mL
50 mM	0.04 mL	0.21 mL	0.43 mL

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产品说明书 for CL 316243 disodium salt

分析证书/产品说明书

化学品安全技术说明书

参考文献 for CL 316243 disodium salt

参考文献是支持产品生物活性的出版物。

Bloom et al (1992) Disodium(R,R)-5-[2-[[2-(3-chlorophenyl)-2-hydroxyethyl]-amino]propyl]-1,3-benzodioxole-2,2-dicarboxylate (CL 316,243). A potent β-adrenergic agonist virtually specific for β3 receptors. A promising antidiabetic and a J.Med.Chem. 35 3081 PMID: 1354264

Woods et al (2001) Efficacy of the β3-adrenergic receptor agonist CL-316243 on experimental bladder hyperflexia and detrusor instability in the rat. J.Urol. 166 1142 PMID: 11490313

Yoshida et al (1994) Anti-obesity and anti-diabetic effects of CL 316,243, a highly specific β₃-adrenoceptor agonist, in yellow KK mice. Life Sci. 54 491 PMID: 8309351

If you know of a relevant reference for CL 316243 disodium salt, please let us know.

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关键词: CL 316243 disodium salt, CL 316243 disodium salt supplier, selective, β3-adrenoceptor, b3-adrenoceptor, β3-adrenergic, b3-adrenergic, agonists, Receptors, CL316243, disodium, salt, 151126-84-0, Adrenergic, Beta-3, 1499, Tocris Bioscience

21 篇 CL 316243 disodium salt 的引用文献

引用文献是使用了 Tocris 产品的出版物。 CL 316243 disodium salt 的部分引用包括：

Nagai et al (2015) Pulmonary Macrophages Attenuate Hypoxic Pulmonary Vasoconstriction via β3AR/iNOS Pathway in Rats Exposed to Chronic Intermittent Hypoxia. PLoS One 10 e0131923 PMID: 26132492

De-Lima-Junior et al (2019) Abnormal brown adipose tissue mitochondrial structure and function in IL10 deficiency. EBioMedicine 39 436 PMID: 30502051

Feng et al (2019) Identification of a rhodanine derivative BML-260 as a potent stimulator of UCP1 expression. Theranostics 9 3501 PMID: 31281493

Li (2017) An additive effect of promoting thermogenic gene expression in mice adipose-derived stromal vascular cells by combination of rosiglit. and CL316,243 Int J Mol Sci 18 E1002 PMID: 28481288

Blaszkiewicz et al (2019) Neuropathy and neural plasticity in the subcutaneous white adipose depot. PLoS One 14 e0221766 PMID: 31509546

Fischer et al (2017) A miR-327-FGF10-FGFR2-mediated autocrine signaling mechanism controls white fat browning. Nat Commun 8 2079 PMID: 29233981

Huang et al (2017) Transcription factor Hlx controls a systematic switch from white to brown fat through Prdm16-mediated co-activation. Nat Commun 8 68 PMID: 28701693

Gonzalez-Hurtado et al (2018) Fatty acid oxidation is required for active and quiescent brown adipose tissue maintenance and thermogenic programing. Mol Metab 7 45 PMID: 29175051

Kashyap et al (2015) Characterization of the role of HCN channels in β3-adrenoceptor mediated rat bladder relaxation. Cell Rep 2 PMID: 26709376

Patsouris et al (2015) Burn Induces Browning of the Subcutaneous White Adipose Tissue in Mice and Humans. Nat Commun 13 1538 PMID: 26586436

Berbée et al (2015) Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development. J Neurosci 6 6356 PMID: 25754609

Rieg et al (2012) Cardiovascular agents affect the tone of pulmonary arteries and veins in precision-cut lung slices. PLoS One 6 e29698 PMID: 22216346

Saxton et al (2018) Role of Sympathetic Nerves and Adipocyte Catecholamine Uptake in the Vasorelaxant Function of Perivascular Adipose Tissue. Arterioscler Thromb Vasc Biol 38 880 PMID: 29496660

Chen et al (2016) Exosomal microRNA miR-92a concentration in serum reflects human brown fat activity. Bladder (San Franc) 7 11420 PMID: 27117818

Enriori et al (2011) Leptin action in the dorsomedial hypothalamus increases sympathetic tone to brown adipose tissue in spite of systemic leptin resistance. Am J Pathol 31 12189 PMID: 21865462

Chen et al (2018) Cbx4 Sumoylates Prdm16 to Regulate Adipose Tissue Thermogenesis. Cell Rep 22 2860 PMID: 29539416

Masand et al (2018) Proteome Imbalance of Mitochondrial Electron Transport Chain in Brown Adipocytes Leads to Metabolic Benefits. Cell Metab 27 616 PMID: 29514069

Mössenböck et al (2014) Browning of white adipose tissue uncouples glucose uptake from Ins signaling. PLoS One 9 e110428 PMID: 25313899

Suárez et al (2014) Oleoylethanolamide enhances β-adrenergic-mediated thermogenesis and white-to-brown adipocyte phenotype in epididymal white adipose tissue in rat. Dis Model Mech 7 129 PMID: 24159189

Pan et al (2014) MicroRNA-378 controls classical brown fat expansion to counteract obesity. Nat Commun 5 4725 PMID: 25145289

Nackley et al (2007) Catechol-O-methyltransferase inhibition increases pain sensitivity through activation of both beta2- and beta3-adrenergic receptors. Pain 128 199 PMID: 17084978

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