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Cl-4AS-1

Cat. No. 3812 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Steroidal androgen receptor agonist
化学名： (4aα,4bβ,6aα,7α,9aβ,9bα,11aβ)-N-(2-Chlorophenyl)-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1,4,6a-trimethyl-2-oxo-1H-indeno[5,4-f]quinoline-7-carboxamide
纯度： ≥99% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Cl-4AS-1

Cl-4AS-1 is a potent steroidal androgen receptor agonist (IC50 = 12 nM). Mimics the action of 5α-dihydrotestosterone (DHT). Transactivates the mouse mammary tumor virus (MMTV) promoter; represses MMP1 promoter activity. Inhibits 5α-reductase type I and II (IC50 values are 6 and 10 nM respectively).

技术数据 for Cl-4AS-1

分子量 441.01
公式 C26H33ClN2O2
储存 Store at RT
纯度 ≥99% (HPLC)
CAS Number 188589-66-4
PubChem ID 90488881
InChI Key CTVXDPDUOKQBKZ-BLIBDJTASA-N
Smiles O=C(NC1=CC=CC=C1Cl)[C@H]2CC[C@@]3([H])[C@]4([H])CC[C@@]5([H])N(C)C(C=C[C@]5(C)[C@@]4([H])CC[C@@]32C)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Cl-4AS-1

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 4.41 10
ethanol 4.41 10

制备储备液 for Cl-4AS-1

以下数据基于产品分子量 441.01。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.1 mM 22.68 mL 113.38 mL 226.75 mL
0.5 mM 4.54 mL 22.68 mL 45.35 mL
1 mM 2.27 mL 11.34 mL 22.68 mL
5 mM 0.45 mL 2.27 mL 4.54 mL

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产品说明书 for Cl-4AS-1

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Cl-4AS-1

参考文献是支持产品生物活性的出版物。

Tolman et al (1997) 4-Methyl-3-oxo-4-aza-5α-androst-1-ene-17β-N-aryl-carboxamides: an approach to combined androgen blockade [5α-reductase inhibition with androgen receptor binding in vitro]. J.Steroid.Biochem.Mol.Biol. 60 303 PMID: 9219921

Schmidt et al (2009) Identification of anabolic selective androgen receptor modulators with reduced activities in reproductive tissues and sebaceous glands. J.Biol.Chem. 284 36367 PMID: 19846549

If you know of a relevant reference for Cl-4AS-1, please let us know.

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关键词: Cl-4AS-1, Cl-4AS-1 supplier, steroidal, androgen, receptors, agonists, Cl-4AS-1, Cl4AS1, transactivates, MMTV, inhibits, 5alpha, 5α, 5a, reductases, inhibitors, Androgen, Receptor, Other, Reductase, 3812, Tocris Bioscience

1 篇 Cl-4AS-1 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Cl-4AS-1 的部分引用包括：

Sarah I et al (2021) Cell-Based Bioassay to Screen Environmental Chemicals and Human Serum for Total Glucocorticogenic Activity. Environ Toxicol Chem 40 177-186 PMID: 33085113

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