Clomipramine hydrochloride

Name: Clomipramine hydrochloride
Brand: Tocris Bioscience
SKU: 0457

Cat. No. 0457 3 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

0457 has been discontinued.

View all 5-HT Transporters products.

说明： 5-HT reuptake inhibitor

化学名： 3-Chloro-10,11-dihydro-N,N-dimethyl-5H-dibenz(Z)[b,f]azepine-5-propanamine hydrochloride

纯度： ≥98% (HPLC)

说明书

引用文献 (3)

文献 (1)

生物活性技术数据说明书参考文献

生物活性 for Clomipramine hydrochloride

Clomipramine hydrochloride is a potent, selective 5-HT uptake blocker. Antidepressant. Binds to the human 5-HT transporter with a K_i of 0.05 nmol/l.

技术数据 for Clomipramine hydrochloride

分子量	351.32
公式	C₁₉H₂₃ClN₂.HCl
储存	Store at RT
纯度	≥98% (HPLC)
CAS Number	17321-77-6
PubChem ID	68539
InChI Key	WIMWMKZEIBHDTH-UHFFFAOYSA-N
Smiles	Cl.CN(C)CCCN1C2=CC(Cl)=CC=C2CCC2=C1C=CC=C2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Clomipramine hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Clomipramine hydrochloride

参考文献是支持产品生物活性的出版物。

McTavish and Benfield (1990) Clomipramine. An overview of its pharmacological properties and a review of its therapeutic use in obsessive compulsive disorder and panic disorder. Drugs 39 136 PMID: 2178909

Ortiz and Artiga (1992) Effects of monoamine uptake inhibitors on extracellular and platelet 5-hydroxytryptamine in rat blood: different effects of clomipramine and fluox. Br.J.Pharmacol. 105 941 PMID: 1387022

Owens et al (1997) Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites. J.Pharmacol.Exp.Ther. 283 1305 PMID: 9400006

Merck Index 12 2447

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关键词: Clomipramine hydrochloride, Clomipramine hydrochloride supplier, 5HT, reuptake, inhibitors, inhibits, Serotonin, Transporters, SERT, 5-Hydroxytryptamine, Monoamine, Neurotransmitter, 5-HT, 0457, Tocris Bioscience

3 篇 Clomipramine hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Clomipramine hydrochloride 的部分引用包括：

Duncan et al (2010) The effects of aging and chronic fluox. treatment on circadian rhythms and suprachiasmatic nucleus expression of neuropeptide genes and 5-HT1B receptors. J Biomed Sci 31 1646 PMID: 20525077

Conley et al (2015) Evaluation of AaDOP2 receptor antagonists reveals antidepressants and antipsychotics as novel lead molecules for control of the yellow fever mosquito, Aedes aegypti. Eur J Neurosci 352 53 PMID: 25332454

Stuart et al (2013) A translational rodent assay of affective biases in depression and antidepressant therapy. Neuropsychopharmacology 38 1625 PMID: 23503126