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Submit ReviewClonidine hydrochloride
说明： α2 agonist. Also I1 ligand
化学名： 2-[(2,6-Dichlorophenyl)amino-2-imidazoline hydrochloride
纯度： ≥99% (HPLC)
生物活性 for Clonidine hydrochloride
Clonidine hydrochloride is a prototypical I1 imidazoline receptor ligand. α2-adrenergic receptor agonist. Antihypertensive. Also thought to enhance autophagy; shown to increase LC3-II levels in PC12 cells.
技术数据 for Clonidine hydrochloride
| 分子量 | 266.56 |
| 公式 | C9H9Cl2N3.HCl |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 4205-91-8 |
| PubChem ID | 20179 |
| InChI Key | ZNIFSRGNXRYGHF-UHFFFAOYSA-N |
| Smiles | Cl[H].ClC1=CC=CC(Cl)=C1\N=C1/NCCN1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Clonidine hydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 26.66 | 100 | |
| DMSO | 13.33 | 50 |
制备储备液 for Clonidine hydrochloride
以下数据基于产品分子量 266.56。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.75 mL | 18.76 mL | 37.52 mL |
| 5 mM | 0.75 mL | 3.75 mL | 7.5 mL |
| 10 mM | 0.38 mL | 1.88 mL | 3.75 mL |
| 50 mM | 0.08 mL | 0.38 mL | 0.75 mL |
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产品说明书 for Clonidine hydrochloride
参考文献 for Clonidine hydrochloride
参考文献是支持产品生物活性的出版物。
Armitsu et al (1998) Mechanism of relaxant effect of clon. in isolated bovine tracheal smooth muscle. J.Pharmacol.Exp.Ther. 286 681 PMID: 9694921
Ernsberger et al (1987) clon. binds to imidazole binding sites as well as α2-adrenoceptors in the ventrolateral medulla. Eur.J.Pharmacol. 134 1 PMID: 3030779
Greney et al (1994) Isolation of a human cerebral imidazoline-specific binding protein. Eur.J.Pharmacol. 265 R1 PMID: 7883019
Silva et al (1996) Dual effect of clon. on mesenteric artery adrenoreceptors: agonistic (alpha-2) and antagonistic (alpha-1). J.Pharmacol.Exp.ther. 277 872 PMID: 8627569
Merck Index 12 2450
Williams et al (2008) Novel targets for Huntington's disease in an mTOR-independent autophagy pathway. Nat.Chem.Biol. 4 295 PMID: 18391949
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关键词: Clonidine hydrochloride, Clonidine hydrochloride supplier, α2-adrenoceptor, alpha2-adrenoceptor, a2-adrenergic, α2-Adrenergic, alpha2-Adrenergic, a2-adrenoceptor, agonists, I1, ligand, Receptors, Imidazoline, Adrenergic, Alpha-2, Autophagy, 0690, Tocris Bioscience
9 篇 Clonidine hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Clonidine hydrochloride 的部分引用包括：
Yuen et al (2014) Synergistic regulation of glutamatergic transmission by serotonin and NE reuptake inhibitors in prefrontal cortical neurons. J Biol Chem 289 25177 PMID: 25056951
Harris et al (2018) Dorsal BNST α2A-Adrenergic Receptors Produce HCN-Dependent Excitatory Actions That Initiate Anxiogenic Behaviors. J Neurosci 38 8922 PMID: 30150361
Okun et al (2011) Transient inflammation-induced ongoing pain is driven by TRPV1 sensitive afferents. Purinergic Signal 7 4 PMID: 21219650
Liu et al (2011) Ongoing pain in the MIA model of osteoarthritis. Neurosci Lett 493 72 PMID: 21241772
Kim et al (2011) Icilin-evoked behavioral stimulation is attenuated by alpha2-adrenoceptor activation. Brain Res 1384 110 PMID: 21315691
Cinelli et al (2013) Suppression of the cough reflex by α 2-adrenergic receptor agonists in the rabbit. Physiol Rep 1 e00122 PMID: 24400133
Garzón et al (2009) Gz mediates the long-lasting desensitization of brain CB1 receptors and is essential for cross-tolerance with mor. Mol Pain 5 11 PMID: 19284549
Devoto et al (2015) Selective inhibition of DA-β-hydroxylase enhances DA release from noradrenergic terminals in the medial prefrontal cortex. Mol Pain 5 e00393 PMID: 26516613
Asiedu et al (2012) Modulation of spinal GABAergic analgesia by inhibition of chloride extrusion capacity in mice. J Pain 13 546 PMID: 22537560
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Clonidine hydrochloride 的评论
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Behavioral pharmacology studies in rodents.
By
Anonymous on 01/04/2018
分析类型： In Vivo
种属： Rat
Behavioral pharmacology. Systemic blockade of alpha2- noradrenergic receptors. Dissolved in water at doses of 0.01-1.0 mg/mL and injected systemically in rats. Has sedative effects on motor movement.
High doses (great than 1 mg/kg) results in self-injurious behavior in rats.
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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