Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewCM 10
说明： ALDH1A inhibitor; depletes CD133+ cancer stem cells
化学名： 2-(2-Propen-1-yl)-6-[[(1-propyl-1H-benzimidazol-2-yl)amino]methyl]phenol
纯度： ≥98% (HPLC)
生物活性 for CM 10
CM 10 is a aldehyde dehydrogenase 1A (ALDH1A) inhibitor (IC50 values are 0.64, 0.74 and 1.7 μM for ALDH1A3, ALDH1A2 and ALDH1A1, respectively). Induces a necroptotic phenotype and preferentially depletes CD133+ ovarian cancer stem cells in vitro.
技术数据 for CM 10
| 分子量 | 321.42 |
| 公式 | C20H23N3O |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 692269-09-3 |
| PubChem ID | 889692 |
| InChI Key | ZFHWEWJDCFGRBO-UHFFFAOYSA-N |
| Smiles | CCCN1C(NCC2=C(O)C(CC=C)=CC=C2)=NC2=CC=CC=C12 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for CM 10
参考文献 for CM 10
参考文献是支持产品生物活性的出版物。
Chefetz et al (2019) A pan-ALDH1A inhibitor induces necroptosis in ovarian cancer stem-like cells. Cell Rep. 26 3061 PMID: 30865894
Morgan & Hurley (2015) Development of a high-throughput in vitro assay to identify selective inhibitors for human ALDH1A1. Chem.Biol.Interact. 234 29 PMID: 25450233
按产品操作查看相关产品
关键词: CM 10, CM 10 supplier, CM10, aldehyde, dehydrogenase, inhibitors, inhibits, ALDH1A, cancer, stem, cells, Aldehyde, Dehydrogenase, Cancer, Stem, Cells, 6933, Tocris Bioscience
CM 10 的评论
目前没有该产品的评论。 Be the first to review CM 10 and earn rewards!
Have you used CM 10?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image