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Submit ReviewCNV Dopamine
说明： Caged dopamine; photolysed by UV light
纯度： ≥98% (HPLC)
生物活性 for CNV Dopamine
CNV Dopamine is a carboxynitroveratryl (CNV)-caged dopamine (Cat. No. 3548); releases dopamine upon ultraviolet light stimulation (365 nm). Induces dopaminergic currents upon photolysis in brain slices expressing wild-type or GFP-labeled D2 receptors. Displays no decrease in current (rundown) with UV light flash duration of up to 100 ms. Pharmacologically inactive prior to photolysis.
技术数据 for CNV Dopamine
| 分子量 | 392.36 |
| 公式 | C18H20N2O8 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| InChI Key | TZSFDUOAUWDBIB-UHFFFAOYSA-N |
| Smiles | OC1=CC(CCN)=CC=C1OC(C(O)=O)C2=CC(OC)=C(OC)C=C2[N+]([O-])=O.NCCC3=CC=C(O)C(OC(C(O)=O)C4=CC(OC)=C(OC)C=C4[N+]([O-])=O)=C3 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for CNV Dopamine
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 39.24 | 100 | |
| water | 19.62 | 50 |
制备储备液 for CNV Dopamine
以下数据基于产品分子量 392.36。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.55 mL | 12.74 mL | 25.49 mL |
| 5 mM | 0.51 mL | 2.55 mL | 5.1 mL |
| 10 mM | 0.25 mL | 1.27 mL | 2.55 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.51 mL |
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产品说明书 for CNV Dopamine
参考文献 for CNV Dopamine
参考文献是支持产品生物活性的出版物。
Robinson et al (2017) Desensitized D2 autoreceptors are resistant to trafficking. Sci.Rep. 7 4379 PMID: 28663556
If you know of a relevant reference for CNV Dopamine, please let us know.
关键词: CNV Dopamine, CNV Dopamine supplier, caged, dopamine, agonists, receptor, Carboxynitroveratryl, CNV, photolysis, Caged, Dopamine, Compounds, Non-selective, 6354, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Dopamine Receptors Scientific Review
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.