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Compstatin

Cat. No. 2585 7 篇引用文献 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： C3-binding peptide; inhibits complement activation
纯度： ≥95% (HPLC)
说明书
引用文献 (7)
评论 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Compstatin

Compstatin is a complement inhibitor; binds C3 inhibiting proteolytic cleavage by C3 convertase (IC50 = 28 μM) and activation of classical and alternative complement pathways (IC50 values are 63 and 12 μM respectively). Prolongs graft survival and reduces hyperacute rejection of ex vivo pig kidneys perfused with human blood and inhibits in vivo heparin/protamine-induced complement activation in primates.

Control Peptide also available.

技术数据 for Compstatin

分子量 1550.77
公式 C66H99N23O17S2
序列 ICVVQDWGHHRCT

(Modifications: Thr-13 = C-terminal amide, Disulfide bridge: 2-12)
储存 Store at -20°C
纯度 ≥95% (HPLC)
CAS Number 206645-99-0
PubChem ID 25082538
InChI Key RDTRHBCZFDCUPW-KWICJJCGSA-N
Smiles [H]N[C@@H]([C@@H](C)CC)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC2=CNC=N2)NC(=O)[C@H](CC2=CNC=N2)NC(=O)CNC(=O)[C@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)C(C)C)C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(N)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Compstatin

溶解性 Soluble to 2 mg/ml in water

产品说明书 for Compstatin

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Compstatin

参考文献是支持产品生物活性的出版物。

Sahu et al (1996) Inhibition of human complement by a C3-binding peptide isolated from a phage-displayed random peptide library. J.Immunol. 157 884 PMID: 8752942

Fiane et al (1999) Compstatin, a peptide inhibitor of C3, prolongs survival of ex vivo perfused pig xenografts. Xenotransplantation 6 52 PMID: 10355733

Soulika et al (2000) Inhibition of heparin/protamine complex-induced complement activation by compstatin in baboons. Clin.Immunol. 96 212 PMID: 10964539

If you know of a relevant reference for Compstatin, please let us know.

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关键词: Compstatin, Compstatin supplier, C3-binding, protein, inhibits, inhibitors, complement, activation, Convertase, Complement, 2585, Tocris Bioscience

7 篇 Compstatin 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Compstatin 的部分引用包括：

Sun et al (2012) Is asthma related to choroidal neovascularization? Pharmacol Res Perspect 7 e35415 PMID: 22567103

Lee et al (2014) Mesenchymal stem cells infected with Mycoplasma arginini secrete complement C3 to regulate immunoglobulin production in b lymphocytes. Cell Death Dis 5 e1192 PMID: 24763049

Larsen et al (2019) Evasion of Classical Complement Pathway Activation on Plasmodium falciparum-Infected Erythrocytes Opsonized by PfEMP1-Specific IgG. Front Immunol 9 3088 PMID: 30666256

Magge et al (2013) Inhibitors of C5 complement enhance vaccinia virus oncolysis. Cancer Gene Ther 20 342 PMID: 23661042

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Compstatin 的评论

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We have tested whether C3b can enzymatically degrade Amyloid Precursor Protein.
By Ahsan Habib on 01/06/2018
分析类型： In Vitro
种属： Mouse
细胞系/组织： CHO/APPwt

We wanted to investigate whether alpha -secretase like activity in human cord blood serum is mediated by complement C3b enzymatic activity. Compstatin (Cat. No. 2585) pre-incubated in different doses with whole as well as C3 depleted cord blood serum for 15 min at 37°C followed by treatment in CHO/APPwt cells with these premix complexes for 2 h.