Conduritol B epoxide

Cat. No. 7056 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Irreversible glucocerebrosidase (β-glucosidase) inhibitor; used to generate Gaucher disease models

化学名： DL-1,2-Anhydro-myo-Inositol

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Conduritol B epoxide

Conduritol B epoxide is an irreversible glucocerebrosidase (GBA) inhibitor (K_i = 53 μM; IC₅₀ = 4.28 - 9.49 μM). Also inhibitis lysosomal α-glucosidase. Used to generate animal models of Gaucher disease. Accelerates recovery of peripheral nerve injury in mice. Preserves motoneurons and ganglioside distribution at the neuromuscular junction, delays disease onset and improves motor function in a mouse ALS model.

技术数据 for Conduritol B epoxide

分子量	162.14
公式	C₆H₁₀O₅
储存	Store at -20°C
CAS Number	6090-95-5
PubChem ID	119054
InChI Key	ZHMWOVGZCINIHW-FTYOSCRSSA-N
Smiles	O[C@H]1[C@H]2O[C@H]2[C@H](O)[C@@H](O)[C@@H]1O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Conduritol B epoxide

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	16.21	100
	DMSO	16.21	100

制备储备液 for Conduritol B epoxide

以下数据基于产品分子量 162.14。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	6.17 mL	30.84 mL	61.68 mL
5 mM	1.23 mL	6.17 mL	12.34 mL
10 mM	0.62 mL	3.08 mL	6.17 mL
50 mM	0.12 mL	0.62 mL	1.23 mL

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产品说明书 for Conduritol B epoxide

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Conduritol B epoxide

参考文献是支持产品生物活性的出版物。

Witte et al (2010) Ultrasensitive in situ visualization of active glucocerebrosidase molecules. Nat.Chem.Biol. 6 907 PMID: 21079602

Henriques et al (2017) Inhibition of β-glucocerebrosidase activity preserves motor unit integrity in a mouse model of Amyotrophic Lateral Sclerosis. Sci.Rep. 7 5235 PMID: 28701774

Artola et al (2019) Functionalized cyclophellitols are selective glucocerebrosidase inhibitors and induce a bona fide neuropathic Gaucher model in zebrafish. J.Am.Chem.Soc. 141 4214 PMID: 30811188

Kuo et al (2019) In vivo inactivation of glycosidases by conduritol B epoxide and cyclophellitol as revealed by activity-based protein profiling. FEBS J. 286 584 PMID: 30600575

If you know of a relevant reference for Conduritol B epoxide, please let us know.

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关键词: Conduritol B epoxide, Conduritol B epoxide supplier, glucocerebrosidase, acid, lysosomal, beta-glucosidase, glucosylceramide, degradation, inhibitors, inhibits, Gaucher, disease, ALS, amyotrophic, lateral, sclerosis, GBA, Glycosylases, 7056, Tocris Bioscience

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