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Discontinued Product
2409 has been discontinued.
View all Histamine H<sub>3</sub> Receptors products.
说明： Potent and selective H3 receptor antagonist
化学名： N,N-Dimethyl-con-5-enin-3-amine
生物活性 for Conessine
Potent and selective histamine H3 receptor antagonist (pKi values are 7.61 and 8.27 at rat and human H3 receptors respectively). A steroidal alkaloid that displays in vitro antiplasmodial activity (IC50 = 1.04 μM). Also has high affinity for α2C adrenoceptors (pKi = 7.98).
技术数据 for Conessine
| 分子量 | 356.59 |
| 公式 | C24H40N2 |
| 储存 | Store at RT |
| CAS Number | 546-06-5 |
| PubChem ID | 441082 |
| InChI Key | GPLGAQQQNWMVMM-MYAJQUOBSA-N |
| Smiles | [H][C@@]23CC=C1C[C@@H](N(C)C)CC[C@@](C)1[C@]([H])2CC[C@@]45[C@]([H])3CC[C@@]([H])4[C@H](C)N(C)C5 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Conessine
参考文献 for Conessine
参考文献是支持产品生物活性的出版物。
Zirihi et al (2005) Isolation, characterization and antiplasmodial activity of steroidal alkaloids from Funtumia elastica (Preuss) Stapf. Bioorg.Med.Chem.Lett. 15 2637 PMID: 15863333
Zhao et al (2008) The alkaloid conessine and analogues as potent histamine H3 receptor antagonists. J.Med.Chem. 51 5423 PMID: 18683917
Witte et al (2005) Discovery of a novel natural product of unique chemical structure as a potent and selective histamine H3 receptor (H3R) antagonist. Soc.Neurosci.Abstr. 491 19
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关键词: Conessine, Conessine supplier, Potent, selective, H3, receptor, antagonists, Receptors, Histamine, histaminergic, 2409, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Histamine Receptors Scientific Review
Written by Iwan de Esch and Rob Leurs, this review provides a synopsis of the different histamine receptor subtypes and the ligands that act upon them; compounds available from Tocris are listed.
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