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CORM 3

Cat. No. 5320 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Water-soluble carbon monoxide-releasing molecule
别名： Carbon monoxide releasing molecule 3
化学名： Tricarbonylchloro(glycinato)ruthenium
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引用文献
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生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for CORM 3

CORM 3 is a water-soluble carbon monoxide-releasing molecule. Suppresses thrombin-induced nitrite release in BV-2 microglia. Protects isolated rats hearts from reperfusion damage in vitro and is cardioprotective in a rat myocardial infarction model in vivo. Also prolongs survival of transplanted hearts in mice. Exhibits anti-inflammatory and vasorelaxant effects.

技术数据 for CORM 3

分子量 294.61
公式 C5H4ClNO5Ru
储存 Store at -20°C
CAS Number 475473-26-8
PubChem ID 9817618
InChI Key IMFIZOFAMSDJSP-UHFFFAOYSA-L
Smiles [Cl-][Ru++]1([NH2]CC(=O)[O-]1)(C#[O])(C#[O])C#[O]

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for CORM 3

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 29.46 100

制备储备液 for CORM 3

以下数据基于产品分子量 294.61。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.39 mL 16.97 mL 33.94 mL
5 mM 0.68 mL 3.39 mL 6.79 mL
10 mM 0.34 mL 1.7 mL 3.39 mL
50 mM 0.07 mL 0.34 mL 0.68 mL

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参考文献 for CORM 3

参考文献是支持产品生物活性的出版物。

Bani-Hani et al (2006) Modulation of thrombin-induced neuroinflammation in BV-2 microglia by carbon monoxide-releasing molecule 3. J.Pharmacol.Exp.Ther. 318 1315 PMID: 16772536

Filippo et al (2012) Acute myocardial infarction in streptozotocin-induced hyperglycaemic rats: protection by a carbon monoxide-releasing molecule (CORM-3). Naunyn Schmiedebergs Arch.Pharmacol. 385 137 PMID: 22038495

Clark et al (2003) Cardioprotective actions by a water-soluble carbon monoxide-releasing molecule. Circ.Res. 93 e2 PMID: 12842916

Foresti et al (2004) Vasoactive properties of CORM-3, a novel water-soluble carbon monoxide-releasing molecule. Br.J.Pharmacol. 142 453 PMID: 15148243

Sawle et al (2005) Carbon monoxide-releasing molecules (CO-RMs) attenuate the inflammatory response elicited by lipopolysaccharide in RAW264.7 murine macrophages. Br.J.Pharmacol. 145 800 PMID: 15880142

If you know of a relevant reference for CORM 3, please let us know.

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关键词: CORM 3, CORM 3 supplier, CORM3, Water-soluble, carbon, monoxide-releasing, molecules, 3, anti-inflammatory, cardioprotective, Carbon, monoxide, releasing, molecule, Miscellaneous, Compounds, ROS, Donors, 5320, Tocris Bioscience

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