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Submit ReviewCortistatin-8
说明： Ghrelin receptor antagonist
别名： CST-8
生物活性 for Cortistatin-8
Synthetic cortistatin analog that lacks the ability to bind somatostatin receptors but retains ghrelin receptor binding. Acts as a ghrelin receptor antagonist; counteracts the response of ghrelin on gastric acid secretion.
技术数据 for Cortistatin-8
| 分子量 | 1009.25 |
| 公式 | C47H68N12O9S2 |
| 序列 |
PCFWKTCK (Modifications: Trp-4 = D-Trp, Disulfide bridge between 2 - 7, Lys-8 = C-terminal amide) |
| 储存 | Desiccate at -20°C |
| CAS Number | 485803-62-1 |
| PubChem ID | 9854662 |
| InChI Key | UHALUVNIZLPZSZ-BPBAYLLVSA-N |
| Smiles | [H]N1CCC[C@H]1C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CC2=CC=CC=C2)NC1=O)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Cortistatin-8
参考文献 for Cortistatin-8
参考文献是支持产品生物活性的出版物。
Luque et al (2006) Cortistatin mimics somatostatin by inducing a dual, dose-dependent stimulatory and inhibitory effect on GH secretion in somatotropes. J.Mol.Endocrinol. 36 547 PMID: 16720722
Sibilia et al (2006) Evidence for a role of the GHS-R1a receptors in ghrelin inhibition of gastric acid secretion in the rat. J.Neuroendocrinol. 18 122 PMID: 16420281
Prodam et al (2008) Cortistatin-8, a synthetic cortistatin-derived ghrelin receptor ligand, does not modify the endocrine responses to acylated ghrelin or hexarelin in humans. Neuropeptides 42 89 PMID: 18061663
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关键词: Cortistatin-8, Cortistatin-8 supplier, Ghrelin, receptor, antagonists, GHS-R1a, Receptors, Growth, Hormone, Secretagogue, 1a, CST8, CST-8, 3033, Tocris Bioscience
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.