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Submit Review(-)-Cotinine
Discontinued Product
3110 has been discontinued.
View all Nicotinic Receptors (Non-selective) products.
说明： Major metabolite of nicotine
化学名： (S)-1-Methyl-5-(3-pyridinyl)-2-pyrrolidinone
纯度： ≥99% (HPLC)
生物活性 for (-)-Cotinine
Major metabolite of nicotine. Shown to activate a subpopulation of α3/α6β2 nAChRs in monkey striatum. Displays cognition-enhancing effects in vivo; reduces amyloid β (Aβ) aggregation and improves memory in an Alzheimer's disease mouse model.
技术数据 for (-)-Cotinine
| 分子量 | 176.22 |
| 公式 | C10H12N2O |
| 储存 | Store at -20°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 486-56-6 |
| PubChem ID | 854019 |
| InChI Key | UIKROCXWUNQSPJ-VIFPVBQESA-N |
| Smiles | CN(C(CC2)=O)[C@@H]2[C@]1=CC=CN=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for (-)-Cotinine
参考文献 for (-)-Cotinine
参考文献是支持产品生物活性的出版物。
Buccafusco and Terry (2003) The potential role of cotinine in the cognitive and neuroprotective actions of nicotine. Life Sci. 72 2931 PMID: 12706481
Terry et al (2005) Cotinine, a neuroactive metabolite of nicotine: potential for treating disorders of impaired cognition. CNS Drug Rev. 11 229 PMID: 16389292
O'Leary et al (2008) Cotinine selectively activates a subpopulation of α3/α6β2 nicotinic receptors in monkey striatum. 325 646 PMID: 18305015
Echeverria et al (2011) Cotinine reduces amyloid-β aggregation and improves memory in Alzheimer's disease mice. J.Alzheimers Dis. 23 1 PMID: 20930295
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关键词: Cotinine, Cotinine supplier, metabolite, nicotine, Acetylcholine, Nicotinic, Receptors, Non-Selective, Subtypes, nAChR, (Non-selective), 3110, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Nicotinic ACh Receptors Scientific Review
Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.