CP 100356 hydrochloride

Cat. No. 4193 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： P-gp inhibitor

化学名： 4-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-N-2[2-(3,4-dimethoxyphenyl)ethyl]-6,7-dimethoxy-2-quinazolinamine hydrochloride

纯度： ≥98% (HPLC)

引用文献 (1)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for CP 100356 hydrochloride

CP 100356 hydrochloride is a high affinity P-glycoprotein (P-gp) inhibitor (K_i values are 58 and 94 nM for mouse Pgp1a and Pgp1b isoforms). Inhibits calcein-AM uptake in MDR1-transfected MDCKII cells (IC₅₀ = 0.5 μM) and prazosin transport in BCRP-transfected MDCKII cells (IC₅₀ = 1.5 μM). Displays weak or no inhibitory activity against MRP1, OATP1B1 and several major human P450 enzymes (IC₅₀ > 50 μM).

许可信息

Sold for research purposes under agreement from Pfizer Inc.

技术数据 for CP 100356 hydrochloride

分子量	597.1
公式	C₃₁H₃₆N₄O₆.HCl
储存	Desiccate at RT
纯度	≥98% (HPLC)
CAS Number	142715-48-8
PubChem ID	71312025
InChI Key	WWCHXVYTCMPAMV-UHFFFAOYSA-N
Smiles	COC2=CC1=C(N3CCC(C=C(OC)C(OC)=C5)=C5C3)N=C(NCCC4=CC=C(OC)C(OC)=C4)N=C1C=C2OC.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for CP 100356 hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	11.94	20

制备储备液 for CP 100356 hydrochloride

以下数据基于产品分子量 597.1。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.2 mM	8.37 mL	41.87 mL	83.74 mL
1 mM	1.67 mL	8.37 mL	16.75 mL
2 mM	0.84 mL	4.19 mL	8.37 mL
10 mM	0.17 mL	0.84 mL	1.67 mL

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产品说明书 for CP 100356 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for CP 100356 hydrochloride

参考文献是支持产品生物活性的出版物。

Taylor et al (1999) The equilibrium and kinetic drug binding properties of the mouse P-gp1a and P-gp1b P-glycoproteins are similar. Br.J.Cancer 81 783 PMID: 10555746

Wandel et al (1999) P-glycoprotein and cytochrome P-450 3A inhibition: dissociation of inhibitory potencies. Cancer Res. 59 3944 PMID: 10463589

Kalgutkar et al (2009) N-(3,4-dimethoxyphenethyl)-4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2[1H]-yl)-6,7-dimethoxyquinazolin-2-amine (CP-100,356) as a "chemical knock-out equivalent" to assess the impact of efflux transporters on oral drug absorption in J.Pharm.Sci. 98 4914 PMID: 19373887

If you know of a relevant reference for CP 100356 hydrochloride, please let us know.

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1 篇 CP 100356 hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 CP 100356 hydrochloride 的部分引用包括：

Sheehy et al (2015) Calcium and P-glycoprotein independent synergism between schweinfurthins and vera. Acta Neuropathol Commun 16 1259 PMID: 26046259

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