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Submit ReviewCP 465022 hydrochloride
说明： Selective and non-competitive AMPA antagonist
化学名： 3-(2-Chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H)-quinazolinone hydrochloride
纯度： ≥99% (HPLC)
生物活性 for CP 465022 hydrochloride
CP 465022 hydrochloride is a selective, non-competitive AMPA antagonist (IC50 = 25 nM in rat cortical neurons) that displays potent anticonvulsant activity. Also significantly blocks the persistent component of Nav1.6 channel activity. Brain penetrant and orally active.
技术数据 for CP 465022 hydrochloride
| 分子量 | 499.41 |
| 公式 | C26H24ClFN4O.HCl |
| 储存 | Desiccate at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 1785666-59-2 |
| PubChem ID | 53251536 |
| InChI Key | YKYDGCRJPYLXHY-GVYCEHEKSA-N |
| Smiles | O=C2N(C3=CC=CC=C3Cl)C(/C=C/C4=NC(CN(CC)CC)=CC=C4)=NC1=CC=C(F)C=C12.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for CP 465022 hydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 49.94 | 100 |
制备储备液 for CP 465022 hydrochloride
以下数据基于产品分子量 499.41。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2 mL | 10.01 mL | 20.02 mL |
| 5 mM | 0.4 mL | 2 mL | 4 mL |
| 10 mM | 0.2 mL | 1 mL | 2 mL |
| 50 mM | 0.04 mL | 0.2 mL | 0.4 mL |
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产品说明书 for CP 465022 hydrochloride
参考文献 for CP 465022 hydrochloride
参考文献是支持产品生物活性的出版物。
Lazaro et al (2002) Functional characterization of CP-465,022, a selective, noncompetitive AMPA receptor antagonist. Neuropharmacology 42 143 PMID: 11804610
Menniti et al (2003) CP-465,022, a selective noncompetitive AMPA receptor antagonist, blocks AMPA receptors but is not neuroprotective in vivo. Stroke 34 171 PMID: 12511770
Welch et al (2008) Traditional AMPA receptor antagonists partially block Nav1.6-mediated persistent current. Neuropharmacology 55 1165 PMID: 18687344
If you know of a relevant reference for CP 465022 hydrochloride, please let us know.
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关键词: CP 465022 hydrochloride, CP 465022 hydrochloride supplier, Selective, non-competitive, AMPA, antagonists, Glutamate, Receptors, iGluR, Ionotropic, CP465022, hydrochloride, 2932, Tocris Bioscience
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