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CPYPP

Cat. No. 4568 1 次引用 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： DOCK2-Rac1 interaction inhibitor
化学名： 4-[3-(2-Chlorophenyl)-2-propen-1-ylidene]-1-phenyl-3,5-pyrazolidinedione
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for CPYPP

CPYPP is a DOCK2-Rac1 interaction inhibitor; suppresses DOCK2-induced Rac1 activation. Also inhibits DOCK1 and DOCK5. Exhibits selectivity over DOCK9. Reduces chemotactic responses in vitro and in vivo, and activates T cells in vitro. Also attenuates HER2-mediated breast cancer cell migration in vitro.

技术数据 for CPYPP

分子量 324.76
公式 C18H13ClN2O2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 310460-39-0
PubChem ID 2248187
InChI Key VVZJFICTTKPNCK-XWDZFIQBSA-N
Smiles O=C(N(C3=CC=CC=C3)NC2=O)/C2=C\C=C\C1=C(Cl)C=CC=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for CPYPP

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 6.5 20

制备储备液 for CPYPP

以下数据基于产品分子量 324.76。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.2 mM 15.4 mL 76.98 mL 153.96 mL
1 mM 3.08 mL 15.4 mL 30.79 mL
2 mM 1.54 mL 7.7 mL 15.4 mL
10 mM 0.31 mL 1.54 mL 3.08 mL

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产品说明书 for CPYPP

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for CPYPP

参考文献是支持产品生物活性的出版物。

Nishikimi et al (2012) Blockade of inflammatory responses by a small-molecule inhibitor of the Rac activator DOCK2. Chem.Biol. 19 488 PMID: 22520755

Laurin et al (2013) Rac-specific guanine nucleotide exchange factor DOCK1 is a critical regulator of HER2-mediated breast cancer metastasis. Proc.Natl.Acad.Sci.U.S.A. 110 7434 PMID: 23592719

If you know of a relevant reference for CPYPP, please let us know.

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关键词: CPYPP, CPYPP supplier, DOCK2, DOCK1, DOCK180, DOCK5, Rac1, interaction, inhibitors, inhibits, Rho, 4568, Tocris Bioscience

1 篇 CPYPP 的引用文献

引用文献是使用了 Tocris 产品的出版物。 CPYPP 的部分引用包括：

Sayan et al (2019) MBD3/NuRD loss participates with KDM6A program to promote DOCK5/8 expression and Rac GTPase activation in human acute myeloid leukemia. FASEB J 33 5268-5286 PMID: 30668141

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CPYPP 的评论

平均评分: 4 (Based on 1 Review.)

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Inhibits cell migration.
By Kishor Pant on 03/24/2023
分析类型： In Vitro
种属： Human
细胞系/组织： HepG2, and Huh

CPYPP inhibited cell migration in HCC in vitro. Image: top panel shows result at 0 h; bottom panel at 48 h.

review image