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Submit ReviewCST 530, Phenol
说明： Functionalized IAP ligand for PROTACs®
化学名： tert-Butyl ((S)-1-(((S)-1-cyclohexyl-2-((2S,4S)-4-(3-hydroxyphenoxy)-2-(((R)-1,2,3,4-tetrahydronaphthalen-1-yl)carbamoyl)pyrrolidin-1-yl)-2-oxoethyl)amino)-1-oxopropan-2-yl)(methyl)carbamate
纯度： ≥95% (HPLC)
生物活性 for CST 530, Phenol
CST 530, Phenol is a functionalized IAP (XIAP and cIAP) ligand for PROTAC® research and development. Supplied with a phenol functional handle for ready conjugation to a linker/target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.
Please contact us for SD files of our available Degrader Building Blocks.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Usage Guidelines for CST 530, Phenol
This product is provided for use in onward chemistry. Suitable solvents can be used.
技术数据 for CST 530, Phenol
| 分子量 | 676.86 |
| 公式 | C38H52N4O7 |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 2241489-43-8 |
| PubChem ID | 138911358 |
| InChI Key | ZAGJVXJUYODMFQ-QEXUPYAZSA-N |
| Smiles | CC(C)(C)OC(N(C)[C@@H](C)C(N[C@@H](C1CCCCC1)C(N2[C@@H](C[C@@H](C2)OC3=CC(O)=CC=C3)C(N[C@H]4C5=CC=CC=C5CCC4)=O)=O)=O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for CST 530, Phenol
参考文献 for CST 530, Phenol
参考文献是支持产品生物活性的出版物。
Ng et al (2023) Heterobifunctional ligase recruiters enable pan-degradation of inhibitor of apoptosis proteins. J.Med.Chem. 66 4703 PMID: 36996313
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关键词: CST 530, Phenol, CST 530, Phenol supplier, CST530, phenol, degraders, degradation, targeted, protein, degrader, E3, ligase, protac, cIAP, cIAP1, IAP2, CRBN, cereblon, Functionalized, Ligase, Ligands, 8066, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Targeted Protein Degradation Poster
Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia