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CX08005

Cat. No. 6144 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Competitive PTP1B inhibitor
化学名： 2-[[[2-(Tetradecyl)phenyl]amino]carbonyl]benzoic acid
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for CX08005

CX08005 is a competitive PTP1B inhibitor (IC50 = 0.781 μM). Binds catalytic P-loop of enzyme. Improves insulin sensitivity in obese mice in the glucose tolerance test and the homeostasis model assessment of insulin resistance index (HOMA-IR). Enhances insulin-induced glucose uptake in adipocytes and myotubes in vitro. Exhibits some selectivity for PTP1B over other protein tyrosine phosphatases, except TCPTP.

技术数据 for CX08005

分子量 453.61
公式 C28H39N04
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 1256341-22-6
PubChem ID 51001376
InChI Key WOEDXTWDPRNPMZ-UHFFFAOYSA-N
Smiles CCCCCCCCCCCCCCOC1=C(C=CC=C1)NC(C2=C(C(O)=O)C=CC=C2)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for CX08005

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 45.36 100
ethanol 45.36 100

制备储备液 for CX08005

以下数据基于产品分子量 453.61。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.2 mL 11.02 mL 22.05 mL
5 mM 0.44 mL 2.2 mL 4.41 mL
10 mM 0.22 mL 1.1 mL 2.2 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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参考文献 for CX08005

参考文献是支持产品生物活性的出版物。

Zhang et al (2016) A novel protein tyrosine phosphatase 1B inhibitor with therapeutic potential for Ins resistance. Br.J.Pharmacol. 173 1939 PMID: 26990621

If you know of a relevant reference for CX08005, please let us know.

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关键词: CX08005, CX08005 supplier, PTP1B, inhibitors, inhibits, protein, tyrosine, phosphatases, T2DM, diabetes, insulin, sensitivity, Protein, Tyrosine, Phosphatases, 6144, Tocris Bioscience

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