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CY 09

Cat. No. 6436 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： NLRP3 inhibitor; active in vivo
化学名： 4-[[4-Oxo-2-thioxo-3-[[3-(trifluoromethyl)phenyl]methyl]-5-thiazolidinylidene]methyl]benzoic acid
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for CY 09

CY 09 is a NLRP3 inhibitor (Kd = 500 nM); directly binds to ATP-binding motif of NLRP3 NACHT domain. Blocks NLRP3 inflammasome assembly and activation. Displays therapeutic effects on mouse models of cryopyrin-associated autoinflammatory syndrome (CAPS) and type 2 diabetes. Exhibits no activity for hERG (10 μM).

技术数据 for CY 09

分子量 423.43
公式 C19H12F3NO3S2
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 1073612-91-5
PubChem ID 44561595
InChI Key DJTINRHPPGAPLD-DHDCSXOGSA-N
Smiles OC(C1=CC=C(C=C1)/C=C2SC(N(C/2=O)CC3=CC(C(F)(F)F)=CC=C3)=S)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for CY 09

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 8.47 20 温和加热

制备储备液 for CY 09

以下数据基于产品分子量 423.43。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.2 mM 11.81 mL 59.04 mL 118.08 mL
1 mM 2.36 mL 11.81 mL 23.62 mL
2 mM 1.18 mL 5.9 mL 11.81 mL
10 mM 0.24 mL 1.18 mL 2.36 mL

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参考文献 for CY 09

参考文献是支持产品生物活性的出版物。

Jiang et al (2017) Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders. J.Exp.Med. 214 3219 PMID: 29021150

If you know of a relevant reference for CY 09, please let us know.

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关键词: CY 09, CY 09 supplier, CY09, inflammasomes, NLRP3, NOD-like, receptors, inhibitors, inhibits, diabetes, anti-inflammatory, ATP, Inflammasomes, 6436, Tocris Bioscience

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