Cyproheptadine hydrochloride

Name: Cyproheptadine hydrochloride
Brand: Tocris Bioscience
SKU: 0996

Cat. No. 0996 2 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

0996 has been discontinued.

View all Non-selective 5-HT<sub>2</sub> products.

说明： 5-HT₂ antagonist

化学名： 4-(5H-Dibenzo[a,d]cyclohepten-5-ylidine)-methylpiperidine hydrochloride

纯度： ≥98% (HPLC)

说明书

引用文献 (2)

文献 (1)

生物活性技术数据说明书参考文献

生物活性 for Cyproheptadine hydrochloride

Non-selective 5HT₂ antagonist, migraine prophylactic. Also SETD7/9 inhibitor (IC₅₀ = 1μM). Decreases expression and increases degradation of estrogen receptor (ER) α in breast tumor MCF7 cells. Inhibits growth of MCF7 xenografts in mice.

技术数据 for Cyproheptadine hydrochloride

分子量	323.86
公式	C₂₁H₂₁N.HCl
储存	Store at RT
纯度	≥98% (HPLC)
CAS Number	969-33-5
PubChem ID	13770
InChI Key	ZPMVNZLARAEGHB-UHFFFAOYSA-N
Smiles	Cl[H].CN1CC\C(CC1)=C1/C2=C(C=CC=C2)C=CC2=C1C=CC=C2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Cyproheptadine hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Cyproheptadine hydrochloride

参考文献是支持产品生物活性的出版物。

Hoyer et al (1994) VII. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol.Rev. 46 157 PMID: 7938165

Moran et al (1994) Inhibitory 5-hydroxytryptamine receptors involved in pressor effects obtained by stimulation of sympathetic outflow from spinal cord in pithed rats. Br.J.Pharmacol. 113 1358 PMID: 7889292

Takemoto et al (2016) Identification of cyprohept. as an inhibitor of SET domain containing lysine methyltransferase 7/9 (Set7/9) that regulates estrogen-dependent transcription. J.Med.Chem. 59 3650 PMID: 27088648

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关键词: Cyproheptadine hydrochloride, Cyproheptadine hydrochloride supplier, 5-HT2, antagonists, Non-Selective, Serotonin, Receptors, antagonism, inhibitors, inhibits, lysine, methyltransferase, SETD7/9, epigenetics, Non-selective, Other, Lysine, Methyltransferases, 0996, Tocris Bioscience

2 篇 Cyproheptadine hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Cyproheptadine hydrochloride 的部分引用包括：

Fouad et al (2010) Locomotion after spinal cord injury depends on constitutive activity in serotonin receptors. J Neurophysiol 104 2975 PMID: 20861436

Murray et al (2010) Recovery of motoneuron and locomotor function after spinal cord injury depends on constitutive activity in 5-HT2C receptors. Nat Med 16 694 PMID: 20512126