Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewCytosporone B
说明： High affinity Nur77 agonist
化学名： Ethyl 3,5-dihydroxy-2-(1-oxooctyl)-benzeneacetate
纯度： ≥98% (HPLC)
生物活性 for Cytosporone B
Cytosporone B is a naturally occurring Nur77 (NR4A1) agonist (Kd = 8.52 x 10-7 M). Induces apoptosis in gastric cancer cells in vitro. Increases blood glucose levels in fasting C57 mice and suppresses xenograft tumor growth. Also exhibits a potent antifibrotic effect in bleomycin-induced skin fibrosis in vivo.
技术数据 for Cytosporone B
| 分子量 | 322.4 |
| 公式 | C18H26O5 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 321661-62-5 |
| PubChem ID | 10687292 |
| InChI Key | UVVWQQKSNZLUQA-UHFFFAOYSA-N |
| Smiles | OC1=CC(CC(OCC)=O)=C(C(CCCCCCC)=O)C(O)=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Cytosporone B
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 32.24 | 100 | |
| ethanol | 32.24 | 100 |
制备储备液 for Cytosporone B
以下数据基于产品分子量 322.4。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.1 mL | 15.51 mL | 31.02 mL |
| 5 mM | 0.62 mL | 3.1 mL | 6.2 mL |
| 10 mM | 0.31 mL | 1.55 mL | 3.1 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.62 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
产品说明书 for Cytosporone B
参考文献 for Cytosporone B
参考文献是支持产品生物活性的出版物。
Palumbo-Zerr et al (2015) Orphan nuclear receptor NR4A1 regulates transforming growth factor-β signaling and fibrosis. Nat.Med. 21 150 PMID: 25581517
Zhan et al (2008) Cytosporone B is an agonist for nuclear orphan receptor Nur77. Nat.Chem.Biol. 4 548 PMID: 18690216
If you know of a relevant reference for Cytosporone B, please let us know.
关键词: Cytosporone B, Cytosporone B supplier, naturally, occurring, high, affinity, Nur77, NR4A1, agonists, agonism, TR3, NGFI-B, TIS1, NAK-1, apoptosis, blood, glucose, antifibrotic, fibrosis, Other, Transcription, Factors, Nerve, Growth, Factor, IB-like, Receptors, 5459, Tocris Bioscience
1 篇 Cytosporone B 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Cytosporone B 的部分引用包括：
Mircea et al (2021) Nr4A1 modulates inflammation-associated intestinal fibrosis and dampens fibrogenic signaling in myofibroblasts. Am J Physiol Gastrointest Liver Physiol 321 G280-G297 PMID: 34288735
您是否知道使用了 Tocris Cytosporone B 的优秀论文？ 请告知我们.
Cytosporone B 的评论
目前没有该产品的评论。 Be the first to review Cytosporone B and earn rewards!
Have you used Cytosporone B?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
MAPK Signaling Scientific Review
MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.
Pathways for Cytosporone B
MAPK Signaling Pathway
The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.