CZC 54252 hydrochloride

Name: CZC 54252 hydrochloride
Brand: Tocris Bioscience
SKU: 4534

Cat. No. 4534 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4534 has been discontinued.

View all LRRK2 products.

说明： Potent LRRK2 inhibitor; neuroprotective

化学名： N-[2-[[5-Chloro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]methanesulfonamide hydrochloride

纯度： ≥98% (HPLC)

说明书

引用文献

文献 (1)

生物活性技术数据说明书参考文献

生物活性 for CZC 54252 hydrochloride

CZC 54252 hydrochloride is a potent inhibitor of leucine-rich repeat kinase 2 (LRRK2) (IC₅₀ values are 1.28 nM and 1.85 nM for wild-type and G2019S mutant forms of LRRK2 respectively). Attenuates neuronal injury induced by LRRK2-G2019S mutant activity in primary human neurons (EC₅₀ = 1 nM).

技术数据 for CZC 54252 hydrochloride

分子量	541.45
公式	C₂₂H₂₅ClN₆O₄S.HCl
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	1784253-05-9
PubChem ID	90488950
InChI Key	KWCBHUPLQMUKAF-UHFFFAOYSA-N
Smiles	ClC1=C(NC3=CC=CC=C3NS(C)(=O)=O)N=C(NC2=C(OC)C=C(N4CCOCC4)C=C2)N=C1.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for CZC 54252 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for CZC 54252 hydrochloride

参考文献是支持产品生物活性的出版物。

Ramsden et al (2011) Chemoproteomics-based design of potent LRRK2-selective lead compounds that attenuate Parkinson's disease-related toxicity in human neurons. ACS Chem.Biol. 6 1021 PMID: 21812418

Kramer et al (2012) Small molecule kinase inhibitors for LRRK2 and their application to Parkinson's disease models. ACS Chem.Neurosci. 3 151 PMID: 22860184

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篇 CZC 54252 hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。

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