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Discontinued Product
0102 has been discontinued.
View all Non-selective Ionotropic Glutamate products.
说明： Broad spectrum glutamatergic antagonist
化学名： D-(-)-2-Amino-4-phosphonobutyric acid
纯度： ≥98% (HPLC)
生物活性 for D-AP4
D-AP4 is a broad spectrum excitatory amino acid receptor antagonist. Also agonist at the quisqualate-sensitized AP6 site in hippocampus where it is less potent than L-AP4.
DL Mixture and L-isomer also available.
技术数据 for D-AP4
| 分子量 | 183.1 |
| 公式 | C4H10NO5P |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 78739-01-2 |
| PubChem ID | 1550579 |
| InChI Key | DDOQBQRIEWHWBT-GSVOUGTGSA-N |
| Smiles | N[C@@]([H])([C@](O)=O)CCP(O)(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for D-AP4
参考文献 for D-AP4
参考文献是支持产品生物活性的出版物。
Davies and Watkins (1982) Actions of D and L forms of 2-amino-5-phosphonovalerate and 2-amino-4-phosphonobutyrate in the cat spinal cord. Brain Res. 235 378 PMID: 6145492
Evans et al (1982) The effect of a series of ω-phosphonic-α-carboxylic amino acids on electrically evoked and amino acid induced responses in isolated spinal cord preparations. Br.J.Pharmacol. 75 65 PMID: 7042024
Schulte et al (1994) Utilization of the resolved L-isomer of 2-amino-6-phosphonhexanoic acid (L-AP6) as a selective agonist for a quisqualate-sensitized site in hippocampal CA1 pyramidal neurons. Brain Res. 649 203 PMID: 7953634
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关键词: D-AP4, D-AP4 supplier, Broad, spectrum, EAA, antagonists, Glutamate, Ionotropic, Non-Selective, iGluR, Receptors, mGlur, Metabotropic, Non-selective, mGlu, 0102, Tocris Bioscience
3 篇 D-AP4 的引用文献
引用文献是使用了 Tocris 产品的出版物。 D-AP4 的部分引用包括：
Sexton et al (2015) Type I intrinsically photosensitive retinal ganglion cells of early post-natal development correspond to the M4 subtype. Neural Dev 10 17 PMID: 26091805
France (2017) Multiple roles of GluN2B-containing NMDA receptors in synaptic plasticity in juvenile hippocampus. Neuropharmacology 112 76 PMID: 27523302
Sexton and Gelder (2015) G-Protein Coupled Receptor Kinase 2 Minimally Regulates Melanopsin Activity in Intrinsically Photosensitive Retinal Ganglion Cells. PLoS One 10 e0128690 PMID: 26069965
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