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说明： TRPC1/6 and Piezo2 inhibitor; resistant to proteolytic digestion
纯度： ≥95% (HPLC)
生物活性 for D-GsMTx4
D-GsMTx4 is a TRPC1/6 and Piezo2 inhibitor. Exhibits same effect as L-enantiomer, GsMTx4 (Cat. No. 4912) on TRPC channels. Inhibits mechanosensitive currents by ~70%. Protects against myocardial infarction in mouse ischemia/reperfusion model. Resistant to proteolytic digestion.
许可信息
Sold under license from The Research Foundation of The State University of New York
技术数据 for D-GsMTx4
| 分子量 | 4095.86 |
| 公式 | C185H273N49O45S6 |
| 序列 |
GCLEFWWKCNPNDDKCCRPKLKCSKLFKLCNFSF (Modifications: All aminoacids = D-aminoacids, Disulfide bridges: 2-17, 9-23, 16-30, Phe-34 = C-terminal amide) |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| InChI Key | WVDNTWXIIKNMHY-CFGROZRMSA-N |
| Smiles | CC(C)C[C@H]1NC(=O)[C@@H](CCCCN)NC(=O)[C@H]2CCCN2C(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@H]2CSSC[C@@H](NC(=O)CN)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CC3=CC=CC=C3)C(=O)N[C@H](CC3=CNC4=CC=CC=C34)C(=O)N[C@H](CC3=CNC4=CC=CC=C34)C(=O)N[C@H](CCCCN)C(=O)N[C@@H]3CSSC[C@@H](NC(=O)[C@@H](CCCCN)NC1=O)C(=O)N[C@H](CO)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CC1=CC=CC=C1)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CSSC[C@@H](NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@@H](CC(N)=O)NC3=O)C(=O)N2)C(=O)N[C@H](CC(N)=O)C(=O)N[C@H](CC1=CC=CC=C1)C(=O)N[C@H](CO)C(=O)N[C@H](CC1=CC=CC=C1)C(N)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for D-GsMTx4
| 溶解性 | Soluble to 1 mg/ml in water |
产品说明书 for D-GsMTx4
参考文献 for D-GsMTx4
参考文献是支持产品生物活性的出版物。
Bae et al (2011) The mechanosensitive ion channel Piezo1 is inhibited by the peptide GsMTx4 Biochemistry 50 6295 PMID: 21696149
Alcaino et al (2017) Mechanosensitive ion channel Piezo2 is inhibited by D-GsMTx4 Channels (Austin) 11 245 PMID: 28085630
Maneshi et al (2018) Enantiomeric Aβ peptides inhibit the fluid shear stress response of PIEZO1 Sci. Rep. 8 14267 PMID: 30250223
Gnanasambandam et al (2017) GsMTx4: Mechanism of Inhibiting Mechanosensitive Ion Channels Biophys.J. 112 31 PMID: 28076814
If you know of a relevant reference for D-GsMTx4, please let us know.
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关键词: D-GsMTx4, D-GsMTx4 supplier, TRPC, transient, receptor, potential, TRPC1, TRPC6, mechanosensitive, ion, channels, MSCs, blockers, blocks, inhibits, inhibitors, venoms, piezo2, Piezo, Channels, 7170, Tocris Bioscience
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