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Submit Review(D)-PPA 1
说明： PD-1/PD-L1 interaction inhibitor
纯度： ≥95% (HPLC)
生物活性 for (D)-PPA 1
(D)-PPA 1 is a PD-1/PD-L1 interaction inhibitor. Binds to PD-L1 (Kd = 0.51 μM). Inhibits interaction at 1 mg/mL in flow cytometry. Inhibits tumor growth and prolongs survival time of mice in vivo.
技术数据 for (D)-PPA 1
| 分子量 | 1555.67 |
| 公式 | C70H98N20O21 |
| 序列 |
NYSKPTDRQYHF (Modifications: Asn-1 = D-Asn, Tyr-2 = D-Tyr, Ser-3 = D-Ser, Lys-4 = D-Lys, Pro-5 = D-Pro, Thr-6 = D-Thr, Asp-7 = D-Asp, Arg-8 = D-Arg, Gln-9 = D-Gln, Tyr-10 = D-Tyr, His-11 = D-His, Phe-12 = D-Phe) |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 1620813-53-7 |
| PubChem ID | 134160249 |
| InChI Key | ZEZZLZKHZPMELC-SDQLLZIZSA-N |
| Smiles | [H]N[C@H](CC(N)=O)C(=O)N[C@H](CC1=CC=C(O)C=C1)C(=O)N[C@H](CO)C(=O)N[C@H](CCCCN)C(=O)N1CCC[C@@H]1C(=O)N[C@H]([C@H](C)O)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H](CC1=CC=C(O)C=C1)C(=O)N[C@H](CC1=CNC=N1)C(=O)N[C@H](CC1=CC=CC=C1)C(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for (D)-PPA 1
| 溶解性 | Soluble to 2 mg/ml in water |
产品说明书 for (D)-PPA 1
参考文献 for (D)-PPA 1
参考文献是支持产品生物活性的出版物。
Chang et al (2015) Blocking of the PD-1/PD-L1 interaction by a D-peptide antagonist for cancer immunotherapy. Angew Chem.Int.Ed.Engl. 54 11760 PMID: 26259671
If you know of a relevant reference for (D)-PPA 1, please let us know.
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关键词: (D)-PPA 1, (D)-PPA 1 supplier, (D)-PPA1, PD-1, PD-L1, programmmed, cell, death, ligand, 1, immune, checkpoint, inhibitors, inhibits, PD1, PDL1, CD279, Other, Apoptosis, Immune, Checkpoints, 6515, Tocris Bioscience
1 篇 (D)-PPA 1 的引用文献
引用文献是使用了 Tocris 产品的出版物。 (D)-PPA 1 的部分引用包括：
Qiang et al (2021) Tumor-associated neutrophils activated by tumor-derived CCL20 (C-C motif chemokine ligand 20) promote T cell immunosuppression via programmed death-ligand 1 (PD-L1) in breast cancer. Bioengineered 12 6996-7006 PMID: 34519637
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