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说明： Potentiator of NMDA recepors; acts at glycine site
生物活性 for D-Serine
D-Serine is a glycine agonist at the NMDA receptor.
技术数据 for D-Serine
| 分子量 | 105.09 |
| 公式 | C3H7NO3 |
| 储存 | Store at RT |
| CAS Number | 312-84-5 |
| PubChem ID | 71077 |
| InChI Key | MTCFGRXMJLQNBG-UWTATZPHSA-N |
| Smiles | N[C@@]([H])([C@](O)=O)CO |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for D-Serine
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 100 |
制备储备液 for D-Serine
以下数据基于产品分子量 105.09。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 9.52 mL | 47.58 mL | 95.16 mL |
| 5 mM | 1.9 mL | 9.52 mL | 19.03 mL |
| 10 mM | 0.95 mL | 4.76 mL | 9.52 mL |
| 50 mM | 0.19 mL | 0.95 mL | 1.9 mL |
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产品说明书 for D-Serine
参考文献 for D-Serine
参考文献是支持产品生物活性的出版物。
Schell et al (1997) D-Serine as a neuromodulator: regional and developmental localizations in rat brain glia resemble NMDA receptors. J. Neurosci. 17 1604 PMID: 9030620
Lodge (1989) Non-competitive NMDA antagonists. The NMDA Receptor (2nd edition). Eds. G.L.Collingr 37
Mothet et al (2000) D-serine is an endogenous ligand for the glycine site of the N-methyl-D-aspartate receptor. Proc.Natl.Acad.Sci.USA 97 4926 PMID: 10781100
If you know of a relevant reference for D-Serine, please let us know.
按产品操作查看相关产品
关键词: D-Serine, D-Serine supplier, Potentiator, glycine, site, Glutamate, NMDA, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, Amino, Acids, 0226, Tocris Bioscience
8 篇 D-Serine 的引用文献
引用文献是使用了 Tocris 产品的出版物。 D-Serine 的部分引用包括：
Morante-Oria et al (2003) Subpallial origin of a population of projecting pioneer neurons during corticogenesis. Proc Natl Acad Sci U S A 100 12468 PMID: 14523241
Romanos et al (2019) Differences in glutamate uptake between cortical regions impact neuronal NMDA receptor activation. Commun Biol 2 127 PMID: 30963115
Laprell et al (2015) Optical control of NMDA receptors with a diffusible photoswitch. Proc Natl Acad Sci U S A 6 8076 PMID: 26311290
Shin et al (2015) Muscarinic regulation of DA and glutamate transmission in the nucleus accumbens. J Neurosci 112 8124 PMID: 26080439
Inoue et al (2008) NMDA- and β-amyloid1-42-induced neurotoxicity is attenuated in serine racemase knock-out mice. PLoS One 28 14486 PMID: 19118183
Potier et al (2010) Contribution of the d-Serine-Dependent Pathway to the Cellular Mechanisms Underlying Cognitive Aging. Front Aging Neurosci 2 1 PMID: 20552041
Adamsky et al (2018) Astrocytic Activation Generates De Novo Neuronal Potentiation and Memory Enhancement. Cell 174 59 PMID: 29804835
Lee et al (2012) Lovastatin modulates glycogen synthase kinase-3β pathway and inhibits mossy fiber sprouting after PilC-induced status epilepticus. J Biol Chem 7 e38789 PMID: 22761705
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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