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说明： Selective PC-PLC inhibitor
化学名： O-(Octahydro-4,7-methano-1H-inden-5-yl) carbonopotassium dithioate
纯度： ≥98% (HPLC)
生物活性 for D609
D609 is a selective competitive phosphatidyl choline-specific phospholipase C (PC-PLC) inhibitor (Ki = 6.4 μM); antiviral and antitumor agent. Also inhibits sphingomyelin synthase. Suppresses LPS- and IFNγ-induced NO production (IC50 = 20 mg/ml) and blocks oxidative glutamate toxicity in nerve cells. Antioxidant in vivo.
技术数据 for D609
| 分子量 | 266.46 |
| 公式 | C11H15OS2K |
| 储存 | Desiccate at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 83373-60-8 |
| PubChem ID | 4234241 |
| InChI Key | IGULCCCBGBDZKQ-UHFFFAOYSA-M |
| Smiles | S=C(S[K])OC1CC2C3CCCC3C1C2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for D609
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 26.65 | 100 |
制备储备液 for D609
以下数据基于产品分子量 266.46。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.75 mL | 18.76 mL | 37.53 mL |
| 5 mM | 0.75 mL | 3.75 mL | 7.51 mL |
| 10 mM | 0.38 mL | 1.88 mL | 3.75 mL |
| 50 mM | 0.08 mL | 0.38 mL | 0.75 mL |
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产品说明书 for D609
参考文献 for D609
参考文献是支持产品生物活性的出版物。
Amtmann (1996) The antiviral, antitumoural xanthate D609 is a competitive inhibitor of phosphatidylcholine-specific phospholipase C. Drugs Exp.Clin.Res. 22 287 PMID: 9034754
Tschiakowsky et al (1994) Induction of nitric oxide synthase activity in phagocytic cells inhibited by tricyclodecan-9-yl-xanthogenate (D609). Br.J.Pharmacol. 113 664 PMID: 7532078
Zhou et al (2001) D609 inhibits ionizing radiation-induced oxidative damage by acting as a potent antioxidant. J.Pharmacol.Exp.Ther. 298 103 PMID: 11408530
Adibhatla et al (2012) Tricyclodecan-9-yl-xanthogenate (D609) mechanism of actions: a mini-review of literature. Neurochem.Res. 37 671 PMID: 22101393
If you know of a relevant reference for D609, please let us know.
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关键词: D609, D609 supplier, Selective, PC-PLC, inhibitors, inhibits, Phospholipases, C, Esterases, Phospholipase, Other, Synthases/Synthetases, Non-selective, Antivirals, 1437, Tocris Bioscience
5 篇 D609 的引用文献
引用文献是使用了 Tocris 产品的出版物。 D609 的部分引用包括：
Pitt et al (2017) Neuroprotective astrocyte-derived Ins/IGF-1 stimulates endocytic processing and extracellular release of neuron-bound Aβ oligomers. Mol Biol Cell 28 2623 PMID: 28963439
Pastor et al (2014) Analysis of ECs and related compounds in plasma: artifactual isomerization and ex vivo enzymatic generation of 2-MGs. J Lipid Res 55 966 PMID: 24610889
Upham et al (2009) Structure-activity-dependent regulation of cell communication by perfluorinated fatty acids using in vivo and in vitro model systems. Environ Health Perspect 117 545 PMID: 19440492
Navratil et al (2014) Francisella tularensis LVS induction of prostaglandin biosynthesis by infected macrophages requires specific host phospholipases and lipid phosphatases. Infect Immun 82 3299 PMID: 24866789
Sovadinova et al (2015) Phosphatidylcholine Specific PLC-Induced Dysregulation of Gap Junctions, a Robust Cellular Response to Environmental Toxicants, and Prevention by Resveratrol in a Rat Liver Cell Model. J Pharmacol Exp Ther 10 e0124454 PMID: 26023933
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D609 的评论
平均评分: 4 (基于 2 条评论。)
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great product.
By
Anonymous on 03/26/2020
分析类型： In Vitro
种属： Rat
细胞系/组织： Hippocampal neuron
100 μM treat 45min
D609 does not inhibit LPA-induced COX-2 expression.
By
Anonymous on 12/13/2018
分析类型： In Vitro
种属： Human
细胞系/组织： Osteosarcoma
Human osteosarcoma cells were incubated with 20 μM D609 for 30 min prior to treatment with 10 μM LPA to estimate COX-2 expression using Western blot analysis. D609 was ineffective against LPA-induced COX-2 expression while other inhibitors showed inhibition.
