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Submit ReviewDADLE
说明： Prototypical δ agonist
别名： [D-Ala2,D-Leu5]-Enkephalin
纯度： ≥95% (HPLC)
生物活性 for DADLE
DADLE is a prototypical δ-opioid receptor agonist that also displays activity at the μ-opioid receptor. Displays antinociceptive activity in vivo.
技术数据 for DADLE
| 分子量 | 569.66 |
| 公式 | C29H39N5O7 |
| 序列 |
YAGFL (Modifications: Ala-2 = D-Ala, Leu-5 = D-Leu) |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 63631-40-3 |
| PubChem ID | 6917707 |
| InChI Key | ZHUJMSMQIPIPTF-IBURTVSXSA-N |
| Smiles | [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@H](C)C(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@H](CC(C)C)C(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for DADLE
| 溶解性 | Soluble to 1 mg/ml in water |
产品说明书 for DADLE
参考文献 for DADLE
参考文献是支持产品生物活性的出版物。
Mulder et al (1991) Pharmacological profile of various κ-agonists at κ-, μ- and δ-opioid receptors mediating presynaptic inhibition of neurotransmitter release in the rat brain. Br.J.Pharmacol. 102 518 PMID: 1673074
Ke et al (2009) Delta opioid agonist [D-Ala2, D-Leu5] enkephalin (DADLE) reduced oxygen-glucose deprivation caused neuronal injury through the MAPK pathway. Brain Res. 1292 100 PMID: 19619518
Suh and Tseng (1990) Different types of opioid receptors mediating analgesia induced by morphine, DAMGO, DPDPE, DADLE and beta-endorphin in mice. Naunyn-Schmied.Arch.Pharmacol. 342 67
If you know of a relevant reference for DADLE, please let us know.
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关键词: DADLE, DADLE supplier, delta-opioid, d-opioid, δ-opioid, receptors, agonists, delta-receptors, prototypical, DOP, OP1, [D-Ala2,, D-Leu5]-Enkephalin, Delta, Opioid, Receptors, 3790, Tocris Bioscience
4 篇 DADLE 的引用文献
引用文献是使用了 Tocris 产品的出版物。 DADLE 的部分引用包括：
Manojkumar A et al (2017) PI3K class II α regulates δ-opioid receptor export from the trans-Golgi network. Mol Biol Cell 28 2202-2219 PMID: 28566554
Shiwarski et al (2017) A PTEN-Regulated Checkpoint Controls Surface Delivery of δ Opioid Receptors. J Neurosci 37 3741 PMID: 28264976
David P et al (2019) Role of RGS12 in the differential regulation of kappa opioid receptor-dependent signaling and behavior. Neuropsychopharmacology 44 1728-1741 PMID: 31141817
Yuan et al (2020) Opposite Roles of δ- and μ-Opioid Receptors in BACE1 Regulation and Alzheimer's Injury. Front Cell Neurosci 14 88 PMID: 32425755
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